PET-based biomarkers in cancer
Positron-emission tomography (PET) is an imaging technique allowing tumor metabolism to be visualized. PET images provide a spatial distribution of the active tumor cells. We use these images to compute quantitative measures and correlate them with clinical data, specifically in breast cancer, brain tumors and other tumor types. The goal is to define PET-based biomarkers of tumor aggressiveness and response to therapies of utility in breast cancer management.
Publications
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Metabolic Activity Grows in Human Cancers Pushed by Phenotypic VariabilityJ.J. Bosque, G.F. Calvo, D. Molina-García, J. Pérez-Beteta, A.M. García Vicente, V. M. Pérez-GarcíaiScience 26(3) 106118 (2023)
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Multiple and diffuse gliomas by 18F-Fluorocholine PET/CT: two sides of the same coinA. M. García Vicente, J. Pérez-Beteta, J. J. Bosque, A. M. Soriano, V. M. Pérez-GarcíaClinical Nuclear Medicine 47(6), e457-e465 (2022)
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SUVmax to tumor perimeter distance: a robust radiomics prognostic biomarker in resectable non-small cell lung cancer patientsG. A. Jiménez-Londoño, A. M. García Vicente, J. J. Bosque, M. Amo-Salas, J. Pérez-Beteta, A. F. Honguero-Martinez, V. M. Pérez-García, A. M. SorianoEuropean Radiology 32, 3889-3902 (2022)
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Evolutionary dynamics at the tumor edge reveals metabolic imaging biomarkersJ. Jiménez-Sánchez, J.J. Bosque, G.A. Jiménez-Londoño, D. Molina-García, A. Martínez-Rubio, J. Pérez-Beteta, C. Ortega-Sabater, A.F Honguero-Martínez, A.M. García-Vicente, G.F. Calvo, V.M. Pérez-GarcíaProceedings of the National Academy of Sciences (USA) 118(6) e2018110118 (2021).
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Segmentation in non-small-cell lung tumors using 18F-fluorodeoxyglucose PET/CT: tips and rules.G.A Jiménez Londoño, J. Pérez-beteta, J.J. Bosque, A.F. Hoguero, A.M García VicenteClinical Nuclear Medicine 45(11) e477-e482 (2020)
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Universal scaling laws rule explosive growth in human cancersV.M. Pérez-García, G.F. Calvo, J.J. Bosque, O. León-Triana, J. Jiménez-Sánchez, J. Pérez-Beteta, J. Belmonte-Beitia, M. Valiente, L. Zhu, P. García-Gómez, P. Sánchez-Gómez, E. Hernández, R. Hortigüela, Y. Azimzade, D. Molina-García, A.Martínez-Rubio, A. Acosta, A. Ortiz de Mendivil, F. Vallette, P. Schucht, M. Murek, M.Pérez-Cano, D.Albillo, AF Honguero, G.A. Jiménez, E. Arana, AM García-VicenteNature Physics 16, 1232-1237 (2020)
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18F-Fluorocholine PET/CT in the prediction of molecular subtypes and prognosis for gliomas.A.M. Garcia Vicente, J. Perez-Beteta, M. Amo-Salas, F.J. Pena Pardo, M. Villena, H. Sandoval, M. Mollejo, R. Barbella, C.J. Klein, J.M. Borras, A.M. Soriano, V.M. Pérez-GarcíaClinical Nuclear Medicine 44(10) e548-e558 (2019).
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Global heterogeneity assessed with 18F-FDG PET/CT. Relation with biological variables and prognosis in locally advanced breast cancer.M.J. Tello-Galán, A.M. García Vicente, J. Pérez-Beteta, M. Amo-Salas, G.A. Jiménez Londoño, F.J. Pena Pardo, A. Soriano, V.M. Pérez GarcíaRev Esp Med Nucl Im Mol 38(5) 290-297 (2019)
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Intratumoral heterogeneity in 18F-FDG PET/CT by textural analysis in breast cancer as predictive and prognostic subrogate.D. Molina A.M. García Vicente, J. Pérez-Beteta, M. Amo-Salas, A. Martínez-González, M.J. Tello Galán, A. Soriano, V.M. Pérez-GarcíaAnnals of Nuclear Medicine 32(6), 379-388 (2018).
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Is it possible to establish the postoperative extent of resection of glioblastoma with 18F-fluorocholine PET/CT?A.M. García Vicente, J. Pérez-Beteta, M. Calvo, M. Villena, A. SorianoClinical Nuclear Medicine 43(8) e269-e273 (2018).
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Assessing response in locally advanced breast cancer treated with neaodjuvant chemotherapy: Predictive and prognostic potential of volume-based metabolic variables with 18F-FDG PET/CTM.D.M. Munoz-Sanchez, A. Soriano, A.M. Garcia-Vicente, M.J. Molina-Garrido, J. Perez-Beteta, A. Olaverri-Herandez, D. Molina-Garcia, J.A.S. Crespo, V.M. Perez-Garcia, E. Val-Pérez, F. Martín-Ordóñez, J.I. Chacón-Muñiz, R. Álvarez-Cabellos, R. Espinosa-Aunión, C. Ortega-Ruipérez, M.J. Cantero, A. Castro, E. Vaquero, E. Catalá, F. Torrecillas and A. Soriano-CastrejónCancer Research 77, P4-01-04 (2017)
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Metabolic tumor burden assessed by dual time point 18F-FDG PET/CT in locally advanced breast cancer: Relation with tumor biology.A.M. García-Vicente, J. Pérez-Beteta, A. Martínez-González, V.M. Pérez-García, D. Molina, G.A. Jiménez Londoño, A. Soriano-CastrejónMolecular Imaging and Biology 19(4), 636-644 (2017)
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Predictive and prognostic potential of volume-based metabolic variables obtained by basal 18F-FDG PET/CT in breast cancer with neoadjuvant chemotherapy indicationA.M. García Vicente, J. Pérez-Beteta, M. Amo-Salas, D. Molina, G. Jiménez Londoño, A. Soriano-Castrejón, M.J. Tello, F.J. Pena Pardo, A. Martínez-GonzálezRevista Española de Medicina Nuclear e Imagen Molecular 37(2), 73-79 (2017)
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Textural features and SUV-based variables assessed by dual time point 18F-FDG PET/CT in locally advanced breast cancerA.M. García-Vicente, D. Molina, J. Pérez-Beteta, M. Amo-Salas, A. Martínez-González, G. Bueno, M.J. Tello-Galán, A. Soriano-CastrejónAnnals of Nuclear Medicine 31(10) 726-735 (2017)
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Metabolic tumor burden assessed by dual time point 18F-FDG PET/CT in breast cancer: Relation with tumor biologyA.M. García Vicente, J. Pérez-Beteta, M. Tello Galán, D. Molina-García, G.J. Londono, V.M. Pérez-García, A. Martínez-González, F.P. Pardo, A. Soriano-CastrejónEuropean Journal of Nuclear Medicine and Molecular Imaging 43, S74-S75 (2016)
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Predictive and prognostic potential of volume-based metabolic variables with F-18-FDG PET/CT in locally advanced breast cancerA.M. García Vicente, J. Pérez-Beteta, M. Tello Galán, D. Molina-García, G. J. Londono, V.M. Pérez-García, A. Martínez-González, F.P. Pardo, A. Soriano-CastrejónEuropean Journal of Nuclear Medicine and Nuclear Imaging 43, S27-S28 (2016)
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Basal 18F-FDG PET/CT as a predictive biomarker of tumor response for neoadjuvant therapy in breast cancerA.M. García Vicente, A. Soriano Castrejón, R.E. Pruneda-González, G.F. Calvo, M.M. Muñoz Sánchez, R. Álvarez Cabellos, R. Espinosa Aunión, F. Relea CalatayudRev Esp Med Nucl Imagen Mol 35(2) (2016) 81-87
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18F -FDG PET/CT characterization of solitary pulmonary nodules: Can we do better?A. García Vicente, V. M. Pérez-García, A. SorianoJournal of Thoracic Disease 7, E215-E218 (2015)
Collaborators
Our research on PET-based biomarkers in cancer is developed in tight collaboration with nuclear medicine physicians from the public health service of Castilla–La Mancha (SESCAM). Ana M. García Vicente, head of the Nuclear Medicine Unit of the Toledo University Hospital is our group’s reference for topics related to PET imaging. Moreover, other members from her team like Germán Jiménez Londoño have worked with us providing clinical insight and collaborating on the imaging data collection and processing.
