Influence of time delay on the dynamics of a mathematical model of CAR-T
M. Szafranska, M. Bodnar, M. J. Piotrowska, M. Krukowski, J. Belmonte-Beitia, U. Forys
Discrete and continuous Dynamical Systems B 38(11), 4498-4515 (2025)
MOLAB authors
Belmonte Beitia, Juan. 
Abstract
We consider a model of CAR-T therapy for glioblastoma, focusing on the influence of time needed for an immune reaction to be triggered. This results in a system of delay differential equations which we investigate, studying the main properties of the model, including the number of steady states and their stability depending on the delay magnitude. Numerical simulations illustrate analytical results. We interpret mathematical results and formulate biological insights.