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BSc in Physics (University of Córdoba, 2014) and PhD in Applied Mathematics (University of Castilla-La Mancha, 2024). Currently, she is a postdoctoral researcher at the Bioinformatics Unit of the Spanish National Cancer Research Centre (CNIO). Her research combines mathematical modeling, image analysis, and machine learning to study cancer dynamics, with a focus on brain tumors. She integrates clinical, imaging, and omics data to identify predictive biomarkers and improve patient-specific treatment strategies.
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Publications
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A clinical decision-support framework to differentiate radiation necrosis from tumor progression in brain metastases
Neuro-oncology Advances (2026) vdag185
B Ocaña-Tienda, ZHC Zhou, A Ramos, A Ortiz, F Nagib, B Asenjo, A Bastero, C Tramblin, E Arana, VM Pérez-García -
Imaging MRI biomarkers for diagnosing brain radionecrosis: focus on incomplete ring enhancement sign
Neuroradiology (2026) doi:0.1007/s00234-026-04096-4
A Ortiz, E Santana, J Perez-Beteta, R Ciervide, J Diamantopoulos, P Martin, JM Sepulveda, A Hernandez-Lain, C Tramblin, S Garcia-Duque, B Ocaña-Tienda, C Rubio, L Koren -
Intercellular adhesion molecule 1 links glioblastoma biology to a scalable prognostic model integrating clinical, imaging, and molecular features
Neuro-oncology Advances (2026) vdag182
S Gandhi, B Ocaña, M Bettencourt, OS Singh, K Devaraja, ER Irish, D Molina, S Karimi, Y Mamatjan, J Sosa, I McIntyre, AF Gao, J Pérez, A Ramos, A Hernández, B Asenjo, M Pino, P Sánchez-Gómez, KD Aldape, C Santos, K Drummond, Ian F Parney, C Velasquez, A Mansouri, VM Pérez-García, G Zadeh, S Mansouri -
Growth dynamics of lung nodules: implications for classification in lung cancer screening
Cancer Imaging 24, 113 (2024)
B. Ocaña-Tienda, A. Eroles-Simó, J. Pérez-Beteta, E. Arana, V. M. Pérez-García -
Mathematical modeling of brain metastases growth and response to therapies: A review
Mathematical Biosciences 373, 109207 (2024)
Beatriz Ocaña-Tienda, Víctor M. Pérez-García -
Morphological MRI features as prognostic indicators in brain metastases
Cancer Imaging 24, 111 (2024)
Ocaña-Tienda B, Pérez-Beteta J, Ortiz de Mendivil A, Asenjo B, Albillo D, Pérez-Romasanta LA, LLorente M, Carballo N, Arana E, Pérez-García VM. -
Radiation necrosis after radiation therapy treatment of brain metastases: A computational approach
PLOS Computational Biology 20(1) e1011400 (2024)
Beatriz Ocana-Tienda, Odelaisy Leon-Triana, Julian Perez-Beteta, Juan Jiménez-Sánchez, Victor M. Perez-Garcia -
Volumetric Analysis: Rethinking Brain Metastases Response Assessment
Neuro-Oncoloy Advances 6(1), 1-9 (2024)
B Ocaña-Tienda, J Pérez-Beteta, JA Romero-Rosales, B Asenjo, A Ortiz, LA Pérez Romasanta, JD Albillo, F Nagib, M Vidal Denis, B. Luque, E. Arana, VM Pérez-García -
A comprehensive dataset of annotated brain metastasis MR images with clinical and radiomic data
Scientific Data 10, 208 (2023)
Ocaña-Tienda B, Pérez-Beteta J, Villanueva JD, Romero JA, Molina D, Suter Y, Asenjo B, Albillo D, Ortiz A, Pérez-Romasanta LA, González E, Llorente M, Carballo N, Nagib F, Vidal M, Luque B, Reyes M, Arana E, Pérez-García VM -
Growth dynamics of brain metastases differentiate radiation necrosis from recurrence
Neurooncology Advances 5(1), vdac179 (2023)
B. Ocaña-Tienda, J. Pérez-Beteta, D. Molina-García, B. Asenjo, A. Ortiz de Mendivil, D. Albillo, LA Pérez-Romasanta, E. González del Portillo, M. Llorente, N. Carballo, E. Arana, Víctor M Pérez-García -
Growth exponents reflect evolutionary processes and treatment response in brain metastases
npj Systems Biology and Applications 9, 35 (2023)
B. Ocaña-Tienda, J. Pérez-Beteta, D. Molina-García, J. Jiménez-Sánchez, O. Leon-Triana, A. Ortiz de Mendivil, B. Asenjo, D. Albillo, L. Pérez-Romasanta, M. Valiente, L. Zhu, P. García- Gómez, E. González-Del Portillo, M. Llorente, N. Carballo, E. Arana, V. M. Pérez-García
Projects
- Model-based digital twins for biomarker development and virtual clinical trials in oncology.
Supported by project SBPLY/24/180225/000193, funded by Junta de Comunidades de Castilla-La Mancha. Spain and European Regional Development Fund (ERDF A way of making Europe). (2025 - 2028) - Establishing a non-invasive approach to accurately diagnose and assess brain tumors
Canadian Cancer Society (2024 - 2027) - Improving New Therapies in Oncology and Related Fields using mathematical models and biomedical data
Ministry of Science and Innovation (National Research Plan) (2023 - 2026) - Mathematical models for the digital transition in neuro-oncology: In-silico design of a clinical trial for glioblastoma.
Ministerio de Ciencia e Innovación (NextGenerationEU) (2023 - 2024) - Validation and transfer of oncological data and biomarkers based on mathematical models (AFTERbioMATH)
Ministry of Science and Innovation (Spain), Proof of Concept Program (2023 - 2024)
Ocaña Tienda, Beatriz
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BSc in Physics (University of Córdoba, 2014) and PhD in Applied Mathematics (University of Castilla-La Mancha, 2024). Currently, she is a postdoctoral researcher at the Bioinformatics Unit of the Spanish National Cancer Research Centre (CNIO). Her research combines mathematical modeling, image analysis, and machine learning to study cancer dynamics, with a focus on brain tumors. She integrates clinical, imaging, and omics data to identify predictive biomarkers and improve patient-specific treatment strategies.
|
Publications
- A clinical decision-support framework to differentiate radiation necrosis from tumor progression in brain metastases
Neuro-oncology Advances (2026) vdag185
B Ocaña-Tienda, ZHC Zhou, A Ramos, A Ortiz, F Nagib, B Asenjo, A Bastero, C Tramblin, E Arana, VM Pérez-García - Imaging MRI biomarkers for diagnosing brain radionecrosis: focus on incomplete ring enhancement sign
Neuroradiology (2026) doi:0.1007/s00234-026-04096-4
A Ortiz, E Santana, J Perez-Beteta, R Ciervide, J Diamantopoulos, P Martin, JM Sepulveda, A Hernandez-Lain, C Tramblin, S Garcia-Duque, B Ocaña-Tienda, C Rubio, L Koren - Intercellular adhesion molecule 1 links glioblastoma biology to a scalable prognostic model integrating clinical, imaging, and molecular features
Neuro-oncology Advances (2026) vdag182
S Gandhi, B Ocaña, M Bettencourt, OS Singh, K Devaraja, ER Irish, D Molina, S Karimi, Y Mamatjan, J Sosa, I McIntyre, AF Gao, J Pérez, A Ramos, A Hernández, B Asenjo, M Pino, P Sánchez-Gómez, KD Aldape, C Santos, K Drummond, Ian F Parney, C Velasquez, A Mansouri, VM Pérez-García, G Zadeh, S Mansouri - Growth dynamics of lung nodules: implications for classification in lung cancer screening
Cancer Imaging 24, 113 (2024)
B. Ocaña-Tienda, A. Eroles-Simó, J. Pérez-Beteta, E. Arana, V. M. Pérez-García - Mathematical modeling of brain metastases growth and response to therapies: A review
Mathematical Biosciences 373, 109207 (2024)
Beatriz Ocaña-Tienda, Víctor M. Pérez-García - Morphological MRI features as prognostic indicators in brain metastases
Cancer Imaging 24, 111 (2024)
Ocaña-Tienda B, Pérez-Beteta J, Ortiz de Mendivil A, Asenjo B, Albillo D, Pérez-Romasanta LA, LLorente M, Carballo N, Arana E, Pérez-García VM. - Radiation necrosis after radiation therapy treatment of brain metastases: A computational approach
PLOS Computational Biology 20(1) e1011400 (2024)
Beatriz Ocana-Tienda, Odelaisy Leon-Triana, Julian Perez-Beteta, Juan Jiménez-Sánchez, Victor M. Perez-Garcia - Volumetric Analysis: Rethinking Brain Metastases Response Assessment
Neuro-Oncoloy Advances 6(1), 1-9 (2024)
B Ocaña-Tienda, J Pérez-Beteta, JA Romero-Rosales, B Asenjo, A Ortiz, LA Pérez Romasanta, JD Albillo, F Nagib, M Vidal Denis, B. Luque, E. Arana, VM Pérez-García - A comprehensive dataset of annotated brain metastasis MR images with clinical and radiomic data
Scientific Data 10, 208 (2023)
Ocaña-Tienda B, Pérez-Beteta J, Villanueva JD, Romero JA, Molina D, Suter Y, Asenjo B, Albillo D, Ortiz A, Pérez-Romasanta LA, González E, Llorente M, Carballo N, Nagib F, Vidal M, Luque B, Reyes M, Arana E, Pérez-García VM - Growth dynamics of brain metastases differentiate radiation necrosis from recurrence
Neurooncology Advances 5(1), vdac179 (2023)
B. Ocaña-Tienda, J. Pérez-Beteta, D. Molina-García, B. Asenjo, A. Ortiz de Mendivil, D. Albillo, LA Pérez-Romasanta, E. González del Portillo, M. Llorente, N. Carballo, E. Arana, Víctor M Pérez-García - Growth exponents reflect evolutionary processes and treatment response in brain metastases
npj Systems Biology and Applications 9, 35 (2023)
B. Ocaña-Tienda, J. Pérez-Beteta, D. Molina-García, J. Jiménez-Sánchez, O. Leon-Triana, A. Ortiz de Mendivil, B. Asenjo, D. Albillo, L. Pérez-Romasanta, M. Valiente, L. Zhu, P. García- Gómez, E. González-Del Portillo, M. Llorente, N. Carballo, E. Arana, V. M. Pérez-García
Projects
- Model-based digital twins for biomarker development and virtual clinical trials in oncology.
Supported by project SBPLY/24/180225/000193, funded by Junta de Comunidades de Castilla-La Mancha. Spain and European Regional Development Fund (ERDF A way of making Europe). (2025 - 2028) - Establishing a non-invasive approach to accurately diagnose and assess brain tumors
Canadian Cancer Society (2024 - 2027) - Improving New Therapies in Oncology and Related Fields using mathematical models and biomedical data
Ministry of Science and Innovation (National Research Plan) (2023 - 2026) - Mathematical models for the digital transition in neuro-oncology: In-silico design of a clinical trial for glioblastoma.
Ministerio de Ciencia e Innovación (NextGenerationEU) (2023 - 2024) - Validation and transfer of oncological data and biomarkers based on mathematical models (AFTERbioMATH)
Ministry of Science and Innovation (Spain), Proof of Concept Program (2023 - 2024)
