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BSc in Physics (University of Córdoba, 2017). MSc in Applied Mathematics (Imperial College London, 2018). PhD in Physics and Mathematics (University of Castilla-La Mancha, 2024). Currently working on data analysis for predicting relapse in childhood leukemia, specifically B-ALL and T-ALL, as well as integrating mathematical models with clinical data to improve the understanding of CAR T-cell therapy in lymphoma.
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Publications
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Computational flow cytometry immunophenotyping at diagnosis is unable to predict relapse in childhood B-cell Acute Lymphoblastic Leukemia
Computers in Biology and Medicine 188, 109831 (2025).
A. Martínez, S. Chulián, A. Niño, R. Picón, J. F. Rodríguez, E. Gálvez, T. Caballero, A. Molinos, A. Castillo, M. Ramírez, M. V. Martínez, A. Míguela, J. L. Fuster, C. Blázquez, V. M. Pérez-García, M. Rosa -
Understanding the role of B cells in CAR T-cell therapy in leukemia through a mathematical model
Chaos 34, 083142 (2024)
S. Serrano, R. Barrio, A. Martínez-Rubio, J. Belmonte-Beitia, V. M. Pérez-García -
Mathematical Modeling of Leukemia Chemotherapy in Bone Marrow
Mathematical Modelling of Natural Phenomena 18, 21 (2023)
Ana Niño-López, Salvador Chulián, Álvaro Martínez-Rubio, Cristina Blázquez-Goñi, María Rosa -
The shape of cancer relapse: Topological data analysis predicts recurrence in paediatric acute lymphoblastic leukaemia
PLOS Computational Biology 19(8) e1011329 (2023)
S. Chulián, B. J. Stolz, A. Martínez-Rubio, C. Blázquez-Goñi, J. F. Rodríguez, T. Caballero, A. Molinos, M. Ramírez-Orellana, A. Castillo, J. L. Fuster, A. Minguela, M. V. Martínez, M. Rosa, V. M. Pérez-García, H. Byrne -
Mathematical models of leukaemia and its treatment: a review
SEMA Journal 79, 441-486 (2022)
S. Chulián, Á. Martínez-Rubio, M. Rosa, V. M. Pérez-García -
Evolutionary dynamics at the tumor edge reveals metabolic imaging biomarkers
Proceedings of the National Academy of Sciences (USA) 118(6) e2018110118 (2021).
J. Jiménez-Sánchez, J.J. Bosque, G.A. Jiménez-Londoño, D. Molina-García, A. Martínez-Rubio, J. Pérez-Beteta, C. Ortega-Sabater, A.F Honguero-Martínez, A.M. García-Vicente, G.F. Calvo, V.M. Pérez-García -
A Mathematical Description of the Bone Marrow Dynamics of CAR T-Cell Therapy in B-cell Childhood Acute Lymphoblastic Leukemia
International J. of Molecular Sciences 22, 6371 (2021)
A. Martínez-Rubio, S. Chulián, C. Blázquez Goñi, A. Pérez Martínez, M. Ramírez Orellana, A. Navarro-Zapata, C. Ferreras, V.M. Pérez-García, M. Rosa -
A mesoscopic simulator to uncover heterogeneity and evolutionary dynamics in tumors
PLoS Computational Biology 17(2) e1008266 (2021).
J. Jiménez-Sánchez, A. Martínez-Rubio, A. Popov, J. Pérez-Beteta, Y. Azimzade, D. Molina-García, J. Belmonte-Beitia, G.F. Calvo, V.M. Pérez-García -
CAR T cell therapy in B-cell acute lymphoblastic leukaemia: Insights from mathematical models
Comm Nonlin Sci Numer Simul 94, 105570 (2021)
O. León-Triana, S. Sabir, G.F. Calvo, J. Belmonte-Beitia, S. Chulian, A. Martínez-Rubio, M. Rosa, A. Pérez-Martínez, M. Ramírez-Orellana, V.M. Pérez-García -
Dynamical properties of feedback signalling in B lymphopoiesis: A mathematical modelling approach
Journal of Theoretical Biology 110685 (2021)
S. Chulián, A. Martínez-Rubio, A. Marciniak-Czochra, T. Stiehl, C.B. Goñi, J.F. Rodríguez Gutiérrez, M.R. Orellana, A.C. Robleda, V.M. Pérez-García, M. Rosa -
High-dimensional Analysis of Single-cell Flow Cytometry Data Predicts Relapse in Childhood Acute Lymphoblastic Leukemia
Cancers 13(1), 17 (2021).
S. Chulián, A. Martínez-Rubio, V.M. Pérez-García, M. Rosa, C. Blázquez-Goñi, J.F. Rodríguez Gutiérrez, L. Hermosín-Ramos, A. Molinos-Quintana, T. Caballero-Velázquez, M. Ramírez-Orellana, A. Castillo Robleda, J.L Fernández-Martínez
Projects
- Mathematical models for the digital transition in neuro-oncology: In-silico design of a clinical trial for glioblastoma.
Ministerio de Ciencia e Innovación (NextGenerationEU) (2023 - 2024) - Mathematics applied to pediatric oncohematology
Ministry of Science and Innovation (National Research Plan) (2023 - 2026) - Validation and transfer of oncological data and biomarkers based on mathematical models (AFTERbioMATH)
Ministry of Science and Innovation (Spain), Proof of Concept Program (2023 - 2024) - Early identification of relapse and treatment optimization in acute lymphoblastic leukaemias through mathematical modelling and discriminant analysis
Junta de Andalucía (2020 - 2023)
Martínez Rubio, Alvaro
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BSc in Physics (University of Córdoba, 2017). MSc in Applied Mathematics (Imperial College London, 2018). PhD in Physics and Mathematics (University of Castilla-La Mancha, 2024). Currently working on data analysis for predicting relapse in childhood leukemia, specifically B-ALL and T-ALL, as well as integrating mathematical models with clinical data to improve the understanding of CAR T-cell therapy in lymphoma.
|
Publications
- Computational flow cytometry immunophenotyping at diagnosis is unable to predict relapse in childhood B-cell Acute Lymphoblastic Leukemia
Computers in Biology and Medicine 188, 109831 (2025).
A. Martínez, S. Chulián, A. Niño, R. Picón, J. F. Rodríguez, E. Gálvez, T. Caballero, A. Molinos, A. Castillo, M. Ramírez, M. V. Martínez, A. Míguela, J. L. Fuster, C. Blázquez, V. M. Pérez-García, M. Rosa - Understanding the role of B cells in CAR T-cell therapy in leukemia through a mathematical model
Chaos 34, 083142 (2024)
S. Serrano, R. Barrio, A. Martínez-Rubio, J. Belmonte-Beitia, V. M. Pérez-García - Mathematical Modeling of Leukemia Chemotherapy in Bone Marrow
Mathematical Modelling of Natural Phenomena 18, 21 (2023)
Ana Niño-López, Salvador Chulián, Álvaro Martínez-Rubio, Cristina Blázquez-Goñi, María Rosa - The shape of cancer relapse: Topological data analysis predicts recurrence in paediatric acute lymphoblastic leukaemia
PLOS Computational Biology 19(8) e1011329 (2023)
S. Chulián, B. J. Stolz, A. Martínez-Rubio, C. Blázquez-Goñi, J. F. Rodríguez, T. Caballero, A. Molinos, M. Ramírez-Orellana, A. Castillo, J. L. Fuster, A. Minguela, M. V. Martínez, M. Rosa, V. M. Pérez-García, H. Byrne - Mathematical models of leukaemia and its treatment: a review
SEMA Journal 79, 441-486 (2022)
S. Chulián, Á. Martínez-Rubio, M. Rosa, V. M. Pérez-García - Evolutionary dynamics at the tumor edge reveals metabolic imaging biomarkers
Proceedings of the National Academy of Sciences (USA) 118(6) e2018110118 (2021).
J. Jiménez-Sánchez, J.J. Bosque, G.A. Jiménez-Londoño, D. Molina-García, A. Martínez-Rubio, J. Pérez-Beteta, C. Ortega-Sabater, A.F Honguero-Martínez, A.M. García-Vicente, G.F. Calvo, V.M. Pérez-García - A Mathematical Description of the Bone Marrow Dynamics of CAR T-Cell Therapy in B-cell Childhood Acute Lymphoblastic Leukemia
International J. of Molecular Sciences 22, 6371 (2021)
A. Martínez-Rubio, S. Chulián, C. Blázquez Goñi, A. Pérez Martínez, M. Ramírez Orellana, A. Navarro-Zapata, C. Ferreras, V.M. Pérez-García, M. Rosa - A mesoscopic simulator to uncover heterogeneity and evolutionary dynamics in tumors
PLoS Computational Biology 17(2) e1008266 (2021).
J. Jiménez-Sánchez, A. Martínez-Rubio, A. Popov, J. Pérez-Beteta, Y. Azimzade, D. Molina-García, J. Belmonte-Beitia, G.F. Calvo, V.M. Pérez-García - CAR T cell therapy in B-cell acute lymphoblastic leukaemia: Insights from mathematical models
Comm Nonlin Sci Numer Simul 94, 105570 (2021)
O. León-Triana, S. Sabir, G.F. Calvo, J. Belmonte-Beitia, S. Chulian, A. Martínez-Rubio, M. Rosa, A. Pérez-Martínez, M. Ramírez-Orellana, V.M. Pérez-García - Dynamical properties of feedback signalling in B lymphopoiesis: A mathematical modelling approach
Journal of Theoretical Biology 110685 (2021)
S. Chulián, A. Martínez-Rubio, A. Marciniak-Czochra, T. Stiehl, C.B. Goñi, J.F. Rodríguez Gutiérrez, M.R. Orellana, A.C. Robleda, V.M. Pérez-García, M. Rosa - High-dimensional Analysis of Single-cell Flow Cytometry Data Predicts Relapse in Childhood Acute Lymphoblastic Leukemia
Cancers 13(1), 17 (2021).
S. Chulián, A. Martínez-Rubio, V.M. Pérez-García, M. Rosa, C. Blázquez-Goñi, J.F. Rodríguez Gutiérrez, L. Hermosín-Ramos, A. Molinos-Quintana, T. Caballero-Velázquez, M. Ramírez-Orellana, A. Castillo Robleda, J.L Fernández-Martínez
Projects
- Mathematical models for the digital transition in neuro-oncology: In-silico design of a clinical trial for glioblastoma.
Ministerio de Ciencia e Innovación (NextGenerationEU) (2023 - 2024) - Mathematics applied to pediatric oncohematology
Ministry of Science and Innovation (National Research Plan) (2023 - 2026) - Validation and transfer of oncological data and biomarkers based on mathematical models (AFTERbioMATH)
Ministry of Science and Innovation (Spain), Proof of Concept Program (2023 - 2024) - Early identification of relapse and treatment optimization in acute lymphoblastic leukaemias through mathematical modelling and discriminant analysis
Junta de Andalucía (2020 - 2023)
