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BSc in Physics (Universidad de Córdoba, 2017). MSc in Applied Mathematics (Imperial College London, 2018). Currently holding a Research Fellowship from Fundación Pablo Ugarte at Cádiz University. His activity focuses on the development of mathematical models for therapy optimisation in childhood Acute Lymphoblastic Leukemia (ALL) treatment. |
Publications
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Understanding the role of B cells in CAR T-cell therapy in leukemia through a mathematical model
Chaos 34, 083142 (2024)
S. Serrano, R. Barrio, A. Martínez-Rubio, J. Belmonte-Beitia, V. M. Pérez-García -
Mathematical Modeling of Leukemia Chemotherapy in Bone Marrow
Mathematical Modelling of Natural Phenomena 18, 21 (2023)
Ana Niño-López, Salvador Chulián, Álvaro Martínez-Rubio, Cristina Blázquez-Goñi, María Rosa -
The shape of cancer relapse: Topological data analysis predicts recurrence in paediatric acute lymphoblastic leukaemia
PLOS Computational Biology 19(8) e1011329 (2023)
S. Chulián, B. J. Stolz, A. Martínez-Rubio, C. Blázquez-Goñi, J. F. Rodríguez, T. Caballero, A. Molinos, M. Ramírez-Orellana, A. Castillo, J. L. Fuster, A. Minguela, M. V. Martínez, M. Rosa, V. M. Pérez-García, H. Byrne -
Mathematical models of leukaemia and its treatment: a review
SEMA Journal 79, 441-486 (2022)
S. Chulián, Á. Martínez-Rubio, M. Rosa, V. M. Pérez-García -
Evolutionary dynamics at the tumor edge reveals metabolic imaging biomarkers
Proceedings of the National Academy of Sciences (USA) 118(6) e2018110118 (2021).
J. Jiménez-Sánchez, J.J. Bosque, G.A. Jiménez-Londoño, D. Molina-García, A. Martínez-Rubio, J. Pérez-Beteta, C. Ortega-Sabater, A.F Honguero-Martínez, A.M. García-Vicente, G.F. Calvo, V.M. Pérez-García -
A Mathematical Description of the Bone Marrow Dynamics of CAR T-Cell Therapy in B-cell Childhood Acute Lymphoblastic Leukemia
International J. of Molecular Sciences 22, 6371 (2021)
A. Martínez-Rubio, S. Chulián, C. Blázquez Goñi, A. Pérez Martínez, M. Ramírez Orellana, A. Navarro-Zapata, C. Ferreras, V.M. Pérez-García, M. Rosa -
A mesoscopic simulator to uncover heterogeneity and evolutionary dynamics in tumors
PLoS Computational Biology 17(2) e1008266 (2021).
J. Jiménez-Sánchez, A. Martínez-Rubio, A. Popov, J. Pérez-Beteta, Y. Azimzade, D. Molina-García, J. Belmonte-Beitia, G.F. Calvo, V.M. Pérez-García -
CAR T cell therapy in B-cell acute lymphoblastic leukaemia: Insights from mathematical models
Comm Nonlin Sci Numer Simul 94, 105570 (2021)
O. León-Triana, S. Sabir, G.F. Calvo, J. Belmonte-Beitia, S. Chulian, A. Martínez-Rubio, M. Rosa, A. Pérez-Martínez, M. Ramírez-Orellana, V.M. Pérez-García -
Dynamical properties of feedback signalling in B lymphopoiesis: A mathematical modelling approach
Journal of Theoretical Biology 110685 (2021)
S. Chulián, A. Martínez-Rubio, A. Marciniak-Czochra, T. Stiehl, C.B. Goñi, J.F. Rodríguez Gutiérrez, M.R. Orellana, A.C. Robleda, V.M. Pérez-García, M. Rosa -
High-dimensional Analysis of Single-cell Flow Cytometry Data Predicts Relapse in Childhood Acute Lymphoblastic Leukemia
Cancers 13(1), 17 (2021).
S. Chulián, A. Martínez-Rubio, V.M. Pérez-García, M. Rosa, C. Blázquez-Goñi, J.F. Rodríguez Gutiérrez, L. Hermosín-Ramos, A. Molinos-Quintana, T. Caballero-Velázquez, M. Ramírez-Orellana, A. Castillo Robleda, J.L Fernández-Martínez
Projects
- Mathematical models for the digital transition in neuro-oncology: In-silico design of a clinical trial for glioblastoma.
Ministerio de Ciencia e Innovación (NextGenerationEU) (2023 - 2024) - Mathematics applied to pediatric oncohematology
Ministry of Science and Innovation (National Research Plan) (2023 - 2026) - Validation and transfer of oncological data and biomarkers based on mathematical models (AFTERbioMATH)
Ministry of Science and Innovation (Spain), Proof of Concept Program (2023 - 2024) - Early identification of relapse and treatment optimization in acute lymphoblastic leukaemias through mathematical modelling and discriminant analysis
Junta de Andalucía (2020 - 2023)
Martínez Rubio, Álvaro
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BSc in Physics (Universidad de Córdoba, 2017). MSc in Applied Mathematics (Imperial College London, 2018). Currently holding a Research Fellowship from Fundación Pablo Ugarte at Cádiz University. His activity focuses on the development of mathematical models for therapy optimisation in childhood Acute Lymphoblastic Leukemia (ALL) treatment. |
Publications
- Understanding the role of B cells in CAR T-cell therapy in leukemia through a mathematical model
Chaos 34, 083142 (2024)
S. Serrano, R. Barrio, A. Martínez-Rubio, J. Belmonte-Beitia, V. M. Pérez-García - Mathematical Modeling of Leukemia Chemotherapy in Bone Marrow
Mathematical Modelling of Natural Phenomena 18, 21 (2023)
Ana Niño-López, Salvador Chulián, Álvaro Martínez-Rubio, Cristina Blázquez-Goñi, María Rosa - The shape of cancer relapse: Topological data analysis predicts recurrence in paediatric acute lymphoblastic leukaemia
PLOS Computational Biology 19(8) e1011329 (2023)
S. Chulián, B. J. Stolz, A. Martínez-Rubio, C. Blázquez-Goñi, J. F. Rodríguez, T. Caballero, A. Molinos, M. Ramírez-Orellana, A. Castillo, J. L. Fuster, A. Minguela, M. V. Martínez, M. Rosa, V. M. Pérez-García, H. Byrne - Mathematical models of leukaemia and its treatment: a review
SEMA Journal 79, 441-486 (2022)
S. Chulián, Á. Martínez-Rubio, M. Rosa, V. M. Pérez-García - Evolutionary dynamics at the tumor edge reveals metabolic imaging biomarkers
Proceedings of the National Academy of Sciences (USA) 118(6) e2018110118 (2021).
J. Jiménez-Sánchez, J.J. Bosque, G.A. Jiménez-Londoño, D. Molina-García, A. Martínez-Rubio, J. Pérez-Beteta, C. Ortega-Sabater, A.F Honguero-Martínez, A.M. García-Vicente, G.F. Calvo, V.M. Pérez-García - A Mathematical Description of the Bone Marrow Dynamics of CAR T-Cell Therapy in B-cell Childhood Acute Lymphoblastic Leukemia
International J. of Molecular Sciences 22, 6371 (2021)
A. Martínez-Rubio, S. Chulián, C. Blázquez Goñi, A. Pérez Martínez, M. Ramírez Orellana, A. Navarro-Zapata, C. Ferreras, V.M. Pérez-García, M. Rosa - A mesoscopic simulator to uncover heterogeneity and evolutionary dynamics in tumors
PLoS Computational Biology 17(2) e1008266 (2021).
J. Jiménez-Sánchez, A. Martínez-Rubio, A. Popov, J. Pérez-Beteta, Y. Azimzade, D. Molina-García, J. Belmonte-Beitia, G.F. Calvo, V.M. Pérez-García - CAR T cell therapy in B-cell acute lymphoblastic leukaemia: Insights from mathematical models
Comm Nonlin Sci Numer Simul 94, 105570 (2021)
O. León-Triana, S. Sabir, G.F. Calvo, J. Belmonte-Beitia, S. Chulian, A. Martínez-Rubio, M. Rosa, A. Pérez-Martínez, M. Ramírez-Orellana, V.M. Pérez-García - Dynamical properties of feedback signalling in B lymphopoiesis: A mathematical modelling approach
Journal of Theoretical Biology 110685 (2021)
S. Chulián, A. Martínez-Rubio, A. Marciniak-Czochra, T. Stiehl, C.B. Goñi, J.F. Rodríguez Gutiérrez, M.R. Orellana, A.C. Robleda, V.M. Pérez-García, M. Rosa - High-dimensional Analysis of Single-cell Flow Cytometry Data Predicts Relapse in Childhood Acute Lymphoblastic Leukemia
Cancers 13(1), 17 (2021).
S. Chulián, A. Martínez-Rubio, V.M. Pérez-García, M. Rosa, C. Blázquez-Goñi, J.F. Rodríguez Gutiérrez, L. Hermosín-Ramos, A. Molinos-Quintana, T. Caballero-Velázquez, M. Ramírez-Orellana, A. Castillo Robleda, J.L Fernández-Martínez
Projects
- Mathematical models for the digital transition in neuro-oncology: In-silico design of a clinical trial for glioblastoma.
Ministerio de Ciencia e Innovación (NextGenerationEU) (2023 - 2024) - Mathematics applied to pediatric oncohematology
Ministry of Science and Innovation (National Research Plan) (2023 - 2026) - Validation and transfer of oncological data and biomarkers based on mathematical models (AFTERbioMATH)
Ministry of Science and Innovation (Spain), Proof of Concept Program (2023 - 2024) - Early identification of relapse and treatment optimization in acute lymphoblastic leukaemias through mathematical modelling and discriminant analysis
Junta de Andalucía (2020 - 2023)
