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“Graduate (1991) PhD (Complutense U., Madrid, 1995). Associate professor (1997) and full professor (2002) in Applied Mathematics at the Mathematics Department of the University of Castilla-La Mancha. He has published more than 170 research papers with more than 11000 Google citations and has an H-index of 52. He is editor in chief of the journal “Physica D: “Nonlinear Phenomena” and serves in the editorial board of “npj Systems Biology and Applications”. He is the coordinator of the Applied Mathematics panel at the Spanish National Research Agency and has been a member of the Marie Curie evaluation committee and of many international project evaluation boards in oncology and/or applied mathematics in France, UK, Poland, Austria, Romania, Cyprus, Latvia, Spain, etc. His main field of research is the application of mathematical modeling to oncology and more specifically to brain tumors, metastasis, cellular immunotherapies, biomarkers, medical images, lymphomas, leukaemias, prostate cancer, etc. In this field he has led several projects funded by public institutions, private foundations such as the James S. Mc. Donnell Foundation and pharmaceutical companies such as NOVARTIS. More specifically he is interested in the development and validation of mechanistic mathematical models that shed light on oncological processes and may be used as platforms to personalize treatments and develop in-silico trials. Also he is interested in the development of mathematical model-based biomarkers of response to treatments.” |
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Evolutionary dynamics at the tumor edge reveals metabolic imaging biomarkers
Proceedings of the National Academy of Sciences (USA) 118(6) e2018110118 (2021).
J. Jiménez-Sánchez, J.J. Bosque, G.A. Jiménez-Londoño, D. Molina-García, A. Martínez-Rubio, J. Pérez-Beteta, C. Ortega-Sabater, A.F Honguero-Martínez, A.M. García-Vicente, G.F. Calvo, V.M. Pérez-García -
A Mathematical Description of the Bone Marrow Dynamics of CAR T-Cell Therapy in B-cell Childhood Acute Lymphoblastic Leukemia
International J. of Molecular Sciences 22, 6371 (2021)
A. Martínez-Rubio, S. Chulián, C. Blázquez Goñi, A. Pérez Martínez, M. Ramírez Orellana, A. Navarro-Zapata, C. Ferreras, V.M. Pérez-García, M. Rosa -
A mesoscopic simulator to uncover heterogeneity and evolutionary dynamics in tumors
PLoS Computational Biology 17(2) e1008266 (2021).
J. Jiménez-Sánchez, A. Martínez-Rubio, A. Popov, J. Pérez-Beteta, Y. Azimzade, D. Molina-García, J. Belmonte-Beitia, G.F. Calvo, V.M. Pérez-García -
Brain Metastasis Response to Stereotactic Radio Surgery: A Mathematical Approach
Mathematics 9(7) 716 (2021)
O. León-Triana, J. Pérez-Beteta, D. Albillo, A. Ortiz de Mendivil, L.A. Pérez-Romasanta, E. González del Portillo, M. Llorente, N. Carballo, E. Arana, V.M. Pérez-García -
CAR T cell therapy in B-cell acute lymphoblastic leukaemia: Insights from mathematical models
Comm Nonlin Sci Numer Simul 94, 105570 (2021)
O. León-Triana, S. Sabir, G.F. Calvo, J. Belmonte-Beitia, S. Chulian, A. Martínez-Rubio, M. Rosa, A. Pérez-Martínez, M. Ramírez-Orellana, V.M. Pérez-García -
CAR T cells for T-cell leukemias: Insights from mathematical models
Comm Nonlin Sci Numer Simul, 96, 105684 (2021)
V.M. Pérez-García, O. León-Triana, M. Rosa, A. Pérez-Martínez -
Dual-Target Car-Ts With on- and off-Tumour Activity May Override Immune Suppression in Solid Cancers: A Mathematical Proof of Concept
Cancers 13, 703 (2021)
O. León-Triana, A. Pérez-Martínez, M. Ramírez-Orellana, V.M. Pérez-García -
Dynamical properties of feedback signalling in B lymphopoiesis: A mathematical modelling approach
Journal of Theoretical Biology 110685 (2021)
S. Chulián, A. Martínez-Rubio, A. Marciniak-Czochra, T. Stiehl, C.B. Goñi, J.F. Rodríguez Gutiérrez, M.R. Orellana, A.C. Robleda, V.M. Pérez-García, M. Rosa -
High-dimensional Analysis of Single-cell Flow Cytometry Data Predicts Relapse in Childhood Acute Lymphoblastic Leukemia
Cancers 13(1), 17 (2021).
S. Chulián, A. Martínez-Rubio, V.M. Pérez-García, M. Rosa, C. Blázquez-Goñi, J.F. Rodríguez Gutiérrez, L. Hermosín-Ramos, A. Molinos-Quintana, T. Caballero-Velázquez, M. Ramírez-Orellana, A. Castillo Robleda, J.L Fernández-Martínez -
In vitro biomimetic models for glioblastoma-a promising tool for drug response studies
Drug Resistance Updates 55, 100753 (2021)
T. Stankovic, T. Randelovic, M. Dragoj, S.S. Buric, L. Fernández, I. Ochoa, V.M. Pérez-García, M. Pesic -
Nonlinear science against the COVID-19 pandemic
Physica D 424 (2021) 132946
V.M. Pérez-García -
Optimal Combinations of Chemotherapy and Radiotherapy in Low-Grade Gliomas: A Mathematical Approach
Journal of Personalized Medicine 2021, 11 (2021) 1036
L. E. Ayala-Hernández, A. Gallegos, P. Schucht, M. Murek, L. A. Pérez-Romasanta, J. Belmonte-Beitia, V. M. Pérez-García -
The interplay of blood flow and temperature in regional hyperthermia: a mathematical approach
Royal Society Open Science 8, 201234 (2021)
J.J. Bosque, G.F. Calvo, V.M Pérez-García, M.C. Navarro
- Establishing a non-invasive approach to accurately diagnose and assess brain tumors
Canadian Cancer Society (2024 - 2027) - Improving New Therapies in Oncology and Related Fields using mathematical models and biomedical data
Ministry of Science and Innovation (National Research Plan) (2023 - 2026) - Mathematical models for the digital transition in neuro-oncology: In-silico design of a clinical trial for glioblastoma.
Ministerio de Ciencia e Innovación (NextGenerationEU) (2023 - 2024) - Optimization of tisagenlecleucel treatments of lymphoma: An integrated human data-based approach using mathematical models
NOVARTIS (2023 - 2025) - Validation and transfer of oncological data and biomarkers based on mathematical models (AFTERbioMATH)
Ministry of Science and Innovation (Spain), Proof of Concept Program (2023 - 2024) - Early identification of relapse and treatment optimization in acute lymphoblastic leukaemias through mathematical modelling and discriminant analysis
Junta de Andalucía (2020 - 2023) - Improving cell therapies in neuroblastoma through mathematical modelling
NeN Association (2020 - 2023) - Mathematical models in Oncology
Ministerio de Ciencia e Innovación (Spain) (2020 - 2023)
“Graduate (1991) PhD (Complutense U., Madrid, 1995). Associate professor (1997) and full professor (2002) in Applied Mathematics at the Mathematics Department of the University of Castilla-La Mancha. He has published more than 170 research papers with more than 11000 Google citations and has an H-index of 52. He is editor in chief of the journal “Physica D: “Nonlinear Phenomena” and serves in the editorial board of “npj Systems Biology and Applications”. He is the coordinator of the Applied Mathematics panel at the Spanish National Research Agency and has been a member of the Marie Curie evaluation committee and of many international project evaluation boards in oncology and/or applied mathematics in France, UK, Poland, Austria, Romania, Cyprus, Latvia, Spain, etc. His main field of research is the application of mathematical modeling to oncology and more specifically to brain tumors, metastasis, cellular immunotherapies, biomarkers, medical images, lymphomas, leukaemias, prostate cancer, etc. In this field he has led several projects funded by public institutions, private foundations such as the James S. Mc. Donnell Foundation and pharmaceutical companies such as NOVARTIS. More specifically he is interested in the development and validation of mechanistic mathematical models that shed light on oncological processes and may be used as platforms to personalize treatments and develop in-silico trials. Also he is interested in the development of mathematical model-based biomarkers of response to treatments.” |
- Evolutionary dynamics at the tumor edge reveals metabolic imaging biomarkers
Proceedings of the National Academy of Sciences (USA) 118(6) e2018110118 (2021).
J. Jiménez-Sánchez, J.J. Bosque, G.A. Jiménez-Londoño, D. Molina-García, A. Martínez-Rubio, J. Pérez-Beteta, C. Ortega-Sabater, A.F Honguero-Martínez, A.M. García-Vicente, G.F. Calvo, V.M. Pérez-García - A Mathematical Description of the Bone Marrow Dynamics of CAR T-Cell Therapy in B-cell Childhood Acute Lymphoblastic Leukemia
International J. of Molecular Sciences 22, 6371 (2021)
A. Martínez-Rubio, S. Chulián, C. Blázquez Goñi, A. Pérez Martínez, M. Ramírez Orellana, A. Navarro-Zapata, C. Ferreras, V.M. Pérez-García, M. Rosa - A mesoscopic simulator to uncover heterogeneity and evolutionary dynamics in tumors
PLoS Computational Biology 17(2) e1008266 (2021).
J. Jiménez-Sánchez, A. Martínez-Rubio, A. Popov, J. Pérez-Beteta, Y. Azimzade, D. Molina-García, J. Belmonte-Beitia, G.F. Calvo, V.M. Pérez-García - Brain Metastasis Response to Stereotactic Radio Surgery: A Mathematical Approach
Mathematics 9(7) 716 (2021)
O. León-Triana, J. Pérez-Beteta, D. Albillo, A. Ortiz de Mendivil, L.A. Pérez-Romasanta, E. González del Portillo, M. Llorente, N. Carballo, E. Arana, V.M. Pérez-García - CAR T cell therapy in B-cell acute lymphoblastic leukaemia: Insights from mathematical models
Comm Nonlin Sci Numer Simul 94, 105570 (2021)
O. León-Triana, S. Sabir, G.F. Calvo, J. Belmonte-Beitia, S. Chulian, A. Martínez-Rubio, M. Rosa, A. Pérez-Martínez, M. Ramírez-Orellana, V.M. Pérez-García - CAR T cells for T-cell leukemias: Insights from mathematical models
Comm Nonlin Sci Numer Simul, 96, 105684 (2021)
V.M. Pérez-García, O. León-Triana, M. Rosa, A. Pérez-Martínez - Dual-Target Car-Ts With on- and off-Tumour Activity May Override Immune Suppression in Solid Cancers: A Mathematical Proof of Concept
Cancers 13, 703 (2021)
O. León-Triana, A. Pérez-Martínez, M. Ramírez-Orellana, V.M. Pérez-García - Dynamical properties of feedback signalling in B lymphopoiesis: A mathematical modelling approach
Journal of Theoretical Biology 110685 (2021)
S. Chulián, A. Martínez-Rubio, A. Marciniak-Czochra, T. Stiehl, C.B. Goñi, J.F. Rodríguez Gutiérrez, M.R. Orellana, A.C. Robleda, V.M. Pérez-García, M. Rosa - High-dimensional Analysis of Single-cell Flow Cytometry Data Predicts Relapse in Childhood Acute Lymphoblastic Leukemia
Cancers 13(1), 17 (2021).
S. Chulián, A. Martínez-Rubio, V.M. Pérez-García, M. Rosa, C. Blázquez-Goñi, J.F. Rodríguez Gutiérrez, L. Hermosín-Ramos, A. Molinos-Quintana, T. Caballero-Velázquez, M. Ramírez-Orellana, A. Castillo Robleda, J.L Fernández-Martínez - In vitro biomimetic models for glioblastoma-a promising tool for drug response studies
Drug Resistance Updates 55, 100753 (2021)
T. Stankovic, T. Randelovic, M. Dragoj, S.S. Buric, L. Fernández, I. Ochoa, V.M. Pérez-García, M. Pesic - Nonlinear science against the COVID-19 pandemic
Physica D 424 (2021) 132946
V.M. Pérez-García - Optimal Combinations of Chemotherapy and Radiotherapy in Low-Grade Gliomas: A Mathematical Approach
Journal of Personalized Medicine 2021, 11 (2021) 1036
L. E. Ayala-Hernández, A. Gallegos, P. Schucht, M. Murek, L. A. Pérez-Romasanta, J. Belmonte-Beitia, V. M. Pérez-García - The interplay of blood flow and temperature in regional hyperthermia: a mathematical approach
Royal Society Open Science 8, 201234 (2021)
J.J. Bosque, G.F. Calvo, V.M Pérez-García, M.C. Navarro
- Establishing a non-invasive approach to accurately diagnose and assess brain tumors
Canadian Cancer Society (2024 - 2027) - Improving New Therapies in Oncology and Related Fields using mathematical models and biomedical data
Ministry of Science and Innovation (National Research Plan) (2023 - 2026) - Mathematical models for the digital transition in neuro-oncology: In-silico design of a clinical trial for glioblastoma.
Ministerio de Ciencia e Innovación (NextGenerationEU) (2023 - 2024) - Optimization of tisagenlecleucel treatments of lymphoma: An integrated human data-based approach using mathematical models
NOVARTIS (2023 - 2025) - Validation and transfer of oncological data and biomarkers based on mathematical models (AFTERbioMATH)
Ministry of Science and Innovation (Spain), Proof of Concept Program (2023 - 2024) - Early identification of relapse and treatment optimization in acute lymphoblastic leukaemias through mathematical modelling and discriminant analysis
Junta de Andalucía (2020 - 2023) - Improving cell therapies in neuroblastoma through mathematical modelling
NeN Association (2020 - 2023) - Mathematical models in Oncology
Ministerio de Ciencia e Innovación (Spain) (2020 - 2023)