|
“Graduate (1991) PhD (Complutense U., Madrid, 1995). Associate professor (1997) and full professor (2002) in Applied Mathematics at the Mathematics Department of the University of Castilla-La Mancha. He has published more than 170 research papers with more than 11000 Google citations and has an H-index of 52. He is editor in chief of the journal “Physica D: “Nonlinear Phenomena” and serves in the editorial board of “npj Systems Biology and Applications”. He is the coordinator of the Applied Mathematics panel at the Spanish National Research Agency and has been a member of the Marie Curie evaluation committee and of many international project evaluation boards in oncology and/or applied mathematics in France, UK, Poland, Austria, Romania, Cyprus, Latvia, Spain, etc. His main field of research is the application of mathematical modeling to oncology and more specifically to brain tumors, metastasis, cellular immunotherapies, biomarkers, medical images, lymphomas, leukaemias, prostate cancer, etc. In this field he has led several projects funded by public institutions, private foundations such as the James S. Mc. Donnell Foundation and pharmaceutical companies such as NOVARTIS. More specifically he is interested in the development and validation of mechanistic mathematical models that shed light on oncological processes and may be used as platforms to personalize treatments and develop in-silico trials. Also he is interested in the development of mathematical model-based biomarkers of response to treatments.” |
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A glance at evolvability: a theoretical analysis of its role in the evolutionary dynamics of cell populations
arXiv:2402.06392
J. Jiménez-Sánchez, C. Ortega-Sabater, P. K. Maini, V.M. Pérez-García, T. Lorenzi -
A Mathematical Model for Fibrous Dysplasia: The Role of the Flow of Mutant Cells
Bulletin of Mathematical Biology 86, 108 (2024)
M. Soloviova, J.C. Beltrán-Vargas, L. Fernández De Castro, J. Belmonte-Beitia, V.M. Pérez-García, M. Caballero -
Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression
EMBO Molecular Medicine 16, 64-92 (2024)
O Molina, C Ortega-Sabater, N Thampi, N Fernández, M Guerrero, A Martínez, M Vinyoles, T Velasco, C Bueno, JL Trincado, I Granada, D Campos, C Giménez, JM Boer , ML den Boer, GF Calvo, Mireia Camós, JL Fuster P Velasco, P Ballerini, F Locatelli, CG Mullighan, DCJ Spierings, F Foijer, VM Pérez-García, P Menéndez -
Growth dynamics of lung nodules: implications for classification in lung cancer screening
Cancer Imaging 24, 113 (2024)
B. Ocaña-Tienda, A. Eroles-Simó, J. Pérez-Beteta, E. Arana, V. M. Pérez-García -
Mathematical model of CAR-T-cell therapy for a B-cell Lymphoma lymph node
arxiv.org/abs/2409.01164
S. Sabir, O. León-Triana, S, Serrano, R, Barrio, V. M. Pérez-García -
Mathematical modeling of brain metastases growth and response to therapies: A review
Mathematical Biosciences 373, 109207 (2024)
Beatriz Ocaña-Tienda, Víctor M. Pérez-García -
Morphological MRI features as prognostic indicators in brain metastases
Cancer Imaging 24, 111 (2024)
Ocaña-Tienda B, Pérez-Beteta J, Ortiz de Mendivil A, Asenjo B, Albillo D, Pérez-Romasanta LA, LLorente M, Carballo N, Arana E, Pérez-García VM. -
Radiation necrosis after radiation therapy treatment of brain metastases: A computational approach
PLOS Computational Biology 20(1) e1011400 (2024)
Beatriz Ocana-Tienda, Odelaisy Leon-Triana, Julian Perez-Beteta, Juan Jiménez-Sánchez, Victor M. Perez-Garcia -
Understanding the role of B cells in CAR T-cell therapy in leukemia through a mathematical model
Chaos 34, 083142 (2024)
S. Serrano, R. Barrio, A. Martínez-Rubio, J. Belmonte-Beitia, V. M. Pérez-García -
Volumetric Analysis: Rethinking Brain Metastases Response Assessment
Neuro-Oncoloy Advances 6(1), 1-9 (2024)
B Ocaña-Tienda, J Pérez-Beteta, JA Romero-Rosales, B Asenjo, A Ortiz, LA Pérez Romasanta, JD Albillo, F Nagib, M Vidal Denis, B. Luque, E. Arana, VM Pérez-García -
A comprehensive dataset of annotated brain metastasis MR images with clinical and radiomic data
Scientific Data 10, 208 (2023)
Ocaña-Tienda B, Pérez-Beteta J, Villanueva JD, Romero JA, Molina D, Suter Y, Asenjo B, Albillo D, Ortiz A, Pérez-Romasanta LA, González E, Llorente M, Carballo N, Nagib F, Vidal M, Luque B, Reyes M, Arana E, Pérez-García VM -
Breaking Down Cell-Free DNA Fragmentation: A Markov Model Approach
biorxiv (doi:10.1101/2023.07.06.547953)
Terence H.L. Tsui, Phil F. Xie, Salvador Chulián, Víctor M. Pérez-García -
Growth exponents reflect evolutionary processes and treatment response in brain metastases
npj Systems Biology and Applications 9, 35 (2023)
B. Ocaña-Tienda, J. Pérez-Beteta, D. Molina-García, J. Jiménez-Sánchez, O. Leon-Triana, A. Ortiz de Mendivil, B. Asenjo, D. Albillo, L. Pérez-Romasanta, M. Valiente, L. Zhu, P. García- Gómez, E. González-Del Portillo, M. Llorente, N. Carballo, E. Arana, V. M. Pérez-García -
Metabolic Activity Grows in Human Cancers Pushed by Phenotypic Variability
iScience 26(3) 106118 (2023)
J.J. Bosque, G.F. Calvo, D. Molina-García, J. Pérez-Beteta, A.M. García Vicente, V. M. Pérez-García -
Overcoming chemotherapy resistance in low-grade gliomas: A computational approach
PLoS Computational Biology 19(11): e1011208 (2023)
Delobel T, Ayala-Hernández LE, Bosque JJ, Pérez-Beteta J, Chulián S, García-Ferrer M, Piñero P, Schucht P, Murek M, Pérez-García VM -
Stochastic Fluctuations Drive Non-genetic Evolution of Proliferation in Clonal Cancer Cell Populations
Bulletin of Mathematical Biology 85(1) 8 (2023)
C Ortega-Sabater, GF Calvo, Jelena Dinic, Ana Podolski, Milica Pesic, VM Perez-Garcia -
The shape of cancer relapse: Topological data analysis predicts recurrence in paediatric acute lymphoblastic leukaemia
PLOS Computational Biology 19(8) e1011329 (2023)
S. Chulián, B. J. Stolz, A. Martínez-Rubio, C. Blázquez-Goñi, J. F. Rodríguez, T. Caballero, A. Molinos, M. Ramírez-Orellana, A. Castillo, J. L. Fuster, A. Minguela, M. V. Martínez, M. Rosa, V. M. Pérez-García, H. Byrne
- Establishing a non-invasive approach to accurately diagnose and assess brain tumors
Canadian Cancer Society (2024 - 2027) - Improving New Therapies in Oncology and Related Fields using mathematical models and biomedical data
Ministry of Science and Innovation (National Research Plan) (2023 - 2026) - Mathematical models for the digital transition in neuro-oncology: In-silico design of a clinical trial for glioblastoma.
Ministerio de Ciencia e Innovación (NextGenerationEU) (2023 - 2024) - Optimization of tisagenlecleucel treatments of lymphoma: An integrated human data-based approach using mathematical models
NOVARTIS (2023 - 2025) - Validation and transfer of oncological data and biomarkers based on mathematical models (AFTERbioMATH)
Ministry of Science and Innovation (Spain), Proof of Concept Program (2023 - 2024) - Early identification of relapse and treatment optimization in acute lymphoblastic leukaemias through mathematical modelling and discriminant analysis
Junta de Andalucía (2020 - 2023) - Improving cell therapies in neuroblastoma through mathematical modelling
NeN Association (2020 - 2023) - Mathematical models in Oncology
Ministerio de Ciencia e Innovación (Spain) (2020 - 2023)
“Graduate (1991) PhD (Complutense U., Madrid, 1995). Associate professor (1997) and full professor (2002) in Applied Mathematics at the Mathematics Department of the University of Castilla-La Mancha. He has published more than 170 research papers with more than 11000 Google citations and has an H-index of 52. He is editor in chief of the journal “Physica D: “Nonlinear Phenomena” and serves in the editorial board of “npj Systems Biology and Applications”. He is the coordinator of the Applied Mathematics panel at the Spanish National Research Agency and has been a member of the Marie Curie evaluation committee and of many international project evaluation boards in oncology and/or applied mathematics in France, UK, Poland, Austria, Romania, Cyprus, Latvia, Spain, etc. His main field of research is the application of mathematical modeling to oncology and more specifically to brain tumors, metastasis, cellular immunotherapies, biomarkers, medical images, lymphomas, leukaemias, prostate cancer, etc. In this field he has led several projects funded by public institutions, private foundations such as the James S. Mc. Donnell Foundation and pharmaceutical companies such as NOVARTIS. More specifically he is interested in the development and validation of mechanistic mathematical models that shed light on oncological processes and may be used as platforms to personalize treatments and develop in-silico trials. Also he is interested in the development of mathematical model-based biomarkers of response to treatments.” |
- A glance at evolvability: a theoretical analysis of its role in the evolutionary dynamics of cell populations
arXiv:2402.06392
J. Jiménez-Sánchez, C. Ortega-Sabater, P. K. Maini, V.M. Pérez-García, T. Lorenzi - A Mathematical Model for Fibrous Dysplasia: The Role of the Flow of Mutant Cells
Bulletin of Mathematical Biology 86, 108 (2024)
M. Soloviova, J.C. Beltrán-Vargas, L. Fernández De Castro, J. Belmonte-Beitia, V.M. Pérez-García, M. Caballero - Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression
EMBO Molecular Medicine 16, 64-92 (2024)
O Molina, C Ortega-Sabater, N Thampi, N Fernández, M Guerrero, A Martínez, M Vinyoles, T Velasco, C Bueno, JL Trincado, I Granada, D Campos, C Giménez, JM Boer , ML den Boer, GF Calvo, Mireia Camós, JL Fuster P Velasco, P Ballerini, F Locatelli, CG Mullighan, DCJ Spierings, F Foijer, VM Pérez-García, P Menéndez - Growth dynamics of lung nodules: implications for classification in lung cancer screening
Cancer Imaging 24, 113 (2024)
B. Ocaña-Tienda, A. Eroles-Simó, J. Pérez-Beteta, E. Arana, V. M. Pérez-García - Mathematical model of CAR-T-cell therapy for a B-cell Lymphoma lymph node
arxiv.org/abs/2409.01164
S. Sabir, O. León-Triana, S, Serrano, R, Barrio, V. M. Pérez-García - Mathematical modeling of brain metastases growth and response to therapies: A review
Mathematical Biosciences 373, 109207 (2024)
Beatriz Ocaña-Tienda, Víctor M. Pérez-García - Morphological MRI features as prognostic indicators in brain metastases
Cancer Imaging 24, 111 (2024)
Ocaña-Tienda B, Pérez-Beteta J, Ortiz de Mendivil A, Asenjo B, Albillo D, Pérez-Romasanta LA, LLorente M, Carballo N, Arana E, Pérez-García VM. - Radiation necrosis after radiation therapy treatment of brain metastases: A computational approach
PLOS Computational Biology 20(1) e1011400 (2024)
Beatriz Ocana-Tienda, Odelaisy Leon-Triana, Julian Perez-Beteta, Juan Jiménez-Sánchez, Victor M. Perez-Garcia - Understanding the role of B cells in CAR T-cell therapy in leukemia through a mathematical model
Chaos 34, 083142 (2024)
S. Serrano, R. Barrio, A. Martínez-Rubio, J. Belmonte-Beitia, V. M. Pérez-García - Volumetric Analysis: Rethinking Brain Metastases Response Assessment
Neuro-Oncoloy Advances 6(1), 1-9 (2024)
B Ocaña-Tienda, J Pérez-Beteta, JA Romero-Rosales, B Asenjo, A Ortiz, LA Pérez Romasanta, JD Albillo, F Nagib, M Vidal Denis, B. Luque, E. Arana, VM Pérez-García - A comprehensive dataset of annotated brain metastasis MR images with clinical and radiomic data
Scientific Data 10, 208 (2023)
Ocaña-Tienda B, Pérez-Beteta J, Villanueva JD, Romero JA, Molina D, Suter Y, Asenjo B, Albillo D, Ortiz A, Pérez-Romasanta LA, González E, Llorente M, Carballo N, Nagib F, Vidal M, Luque B, Reyes M, Arana E, Pérez-García VM - Breaking Down Cell-Free DNA Fragmentation: A Markov Model Approach
biorxiv (doi:10.1101/2023.07.06.547953)
Terence H.L. Tsui, Phil F. Xie, Salvador Chulián, Víctor M. Pérez-García - Growth exponents reflect evolutionary processes and treatment response in brain metastases
npj Systems Biology and Applications 9, 35 (2023)
B. Ocaña-Tienda, J. Pérez-Beteta, D. Molina-García, J. Jiménez-Sánchez, O. Leon-Triana, A. Ortiz de Mendivil, B. Asenjo, D. Albillo, L. Pérez-Romasanta, M. Valiente, L. Zhu, P. García- Gómez, E. González-Del Portillo, M. Llorente, N. Carballo, E. Arana, V. M. Pérez-García - Metabolic Activity Grows in Human Cancers Pushed by Phenotypic Variability
iScience 26(3) 106118 (2023)
J.J. Bosque, G.F. Calvo, D. Molina-García, J. Pérez-Beteta, A.M. García Vicente, V. M. Pérez-García - Overcoming chemotherapy resistance in low-grade gliomas: A computational approach
PLoS Computational Biology 19(11): e1011208 (2023)
Delobel T, Ayala-Hernández LE, Bosque JJ, Pérez-Beteta J, Chulián S, García-Ferrer M, Piñero P, Schucht P, Murek M, Pérez-García VM - Stochastic Fluctuations Drive Non-genetic Evolution of Proliferation in Clonal Cancer Cell Populations
Bulletin of Mathematical Biology 85(1) 8 (2023)
C Ortega-Sabater, GF Calvo, Jelena Dinic, Ana Podolski, Milica Pesic, VM Perez-Garcia - The shape of cancer relapse: Topological data analysis predicts recurrence in paediatric acute lymphoblastic leukaemia
PLOS Computational Biology 19(8) e1011329 (2023)
S. Chulián, B. J. Stolz, A. Martínez-Rubio, C. Blázquez-Goñi, J. F. Rodríguez, T. Caballero, A. Molinos, M. Ramírez-Orellana, A. Castillo, J. L. Fuster, A. Minguela, M. V. Martínez, M. Rosa, V. M. Pérez-García, H. Byrne
- Establishing a non-invasive approach to accurately diagnose and assess brain tumors
Canadian Cancer Society (2024 - 2027) - Improving New Therapies in Oncology and Related Fields using mathematical models and biomedical data
Ministry of Science and Innovation (National Research Plan) (2023 - 2026) - Mathematical models for the digital transition in neuro-oncology: In-silico design of a clinical trial for glioblastoma.
Ministerio de Ciencia e Innovación (NextGenerationEU) (2023 - 2024) - Optimization of tisagenlecleucel treatments of lymphoma: An integrated human data-based approach using mathematical models
NOVARTIS (2023 - 2025) - Validation and transfer of oncological data and biomarkers based on mathematical models (AFTERbioMATH)
Ministry of Science and Innovation (Spain), Proof of Concept Program (2023 - 2024) - Early identification of relapse and treatment optimization in acute lymphoblastic leukaemias through mathematical modelling and discriminant analysis
Junta de Andalucía (2020 - 2023) - Improving cell therapies in neuroblastoma through mathematical modelling
NeN Association (2020 - 2023) - Mathematical models in Oncology
Ministerio de Ciencia e Innovación (Spain) (2020 - 2023)