Gliomas are the most frequent primary brain tumors, originating from glial cells –the neurons’ support cells-. Glioblastomas are the most frequent and malignant type. Low-grade gliomas are slowly growing infiltrative tumors and affect mostly young patients. No substantial therapeutic advances have been found in recent years. We build mathematical models of these tumors, search for the best treatment schedules and/or combinations of currently available therapies in-silico and develop hypotheses to be implemented in the clinics.