Mathematics and radiation therapy
Radiation therapy kills cancer cells or slows their growth by damaging their DNA. External beam radiation therapy is administered typically in fixed doses per day (fractions) sequentially for several weeks. Moderate doses around 2-3 Gy are given in this type of therapy while higher doses per fraction are given in stereotactic radiosurgery, which typically lasts for one week at the most. Also, internal sources of radiation can be placed in the body to deliver the so-called brachytherapy. We use mathematical models to study what is the best way to distribute the doses in time and space to maximize tumor control and minimize toxicity for different tumor types. We also study how to best deliver radiation therapy in combination with other treatments.
Publications
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Morphological MRI features as prognostic indicators in brain metastasesOcaña-Tienda B, Pérez-Beteta J, Ortiz de Mendivil A, Asenjo B, Albillo D, Pérez-Romasanta LA, LLorente M, Carballo N, Arana E, Pérez-García VM.Cancer Imaging 24, 111 (2024)
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Radiation necrosis after radiation therapy treatment of brain metastases: A computational approachBeatriz Ocana-Tienda, Odelaisy Leon-Triana, Julian Perez-Beteta, Juan Jiménez-Sánchez, Victor M. Perez-GarciaPLOS Computational Biology 20(1) e1011400 (2024)
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A comprehensive dataset of annotated brain metastasis MR images with clinical and radiomic dataOcaña-Tienda B, Pérez-Beteta J, Villanueva JD, Romero JA, Molina D, Suter Y, Asenjo B, Albillo D, Ortiz A, Pérez-Romasanta LA, González E, Llorente M, Carballo N, Nagib F, Vidal M, Luque B, Reyes M, Arana E, Pérez-García VMScientific Data 10, 208 (2023)
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Growth exponents reflect evolutionary processes and treatment response in brain metastasesB. Ocaña-Tienda, J. Pérez-Beteta, D. Molina-García, J. Jiménez-Sánchez, O. Leon-Triana, A. Ortiz de Mendivil, B. Asenjo, D. Albillo, L. Pérez-Romasanta, M. Valiente, L. Zhu, P. García- Gómez, E. González-Del Portillo, M. Llorente, N. Carballo, E. Arana, V. M. Pérez-Garcíanpj Systems Biology and Applications 9, 35 (2023)
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Growth dynamics of brain metastases differentiate radiation necrosis from recurrenceB. Ocaña-Tienda, J. Pérez-Beteta, D. Molina-García, B. Asenjo, A. Ortiz de Mendivil, D. Albillo, LA Pérez-Romasanta, E. González del Portillo, M. Llorente, N. Carballo, E. Arana, Víctor M Pérez-GarcíaNeurooncology Advances (2022) vdac179
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Patient-specific forecasting of post-radiotherapy prostate-specific antigen kinetics enables early prediction of biochemical relapseG. Lorenzo, N. di Muzio, C. L. Deantoni, C. Cozzarini, A. Fodor, A. Briganti, F. Montorsi, V. M. Pérez-García, H. Gómez, A. RealiiScience 25, 105430 (2022)
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Brain Metastasis Response to Stereotactic Radio Surgery: A Mathematical ApproachO. León-Triana, J. Pérez-Beteta, D. Albillo, A. Ortiz de Mendivil, L.A. Pérez-Romasanta, E. González del Portillo, M. Llorente, N. Carballo, E. Arana, V.M. Pérez-GarcíaMathematics 9(7) 716 (2021)
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Optimal Combinations of Chemotherapy and Radiotherapy in Low-Grade Gliomas: A Mathematical ApproachL. E. Ayala-Hernández, A. Gallegos, P. Schucht, M. Murek, L. A. Pérez-Romasanta, J. Belmonte-Beitia, V. M. Pérez-GarcíaJournal of Personalized Medicine 2021, 11 (2021) 1036
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The interplay of blood flow and temperature in regional hyperthermia: a mathematical approachJ.J. Bosque, G.F. Calvo, V.M Pérez-García, M.C. NavarroRoyal Society Open Science 8, 201234 (2021)
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Radiation protraction schedules for low-grade gliomas: A comparison between different mathematical modelsI. Budia, A. Álvarez-Arenas, T.E. Wooley, G.F. Calvo, J. Belmonte-BeitiaJournal of the Royal Society of Interface 16, 20190665 (2019)
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Mechanistic modelling of prostate-specific antigen dynamics shows potential for personalized prediction of radiation therapy outcomeG. Lorenzo, V.M. Pérez-García, Alfonso Mariño, L.A. Pérez Romasanta, Alessandro Reali, H. GómezJournal of the Royal Society Interface 20190195 (2019)
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Modulation of antioxidant potential with coenzyme Q10 suppressed invasion of temozolomide resistant rat glioma in vitro and in vivoS. Stojkovic, A. Podolski-Renic, J. Dinic, T. Stankovic, M. Jovanovic, S. Hadžic, J.M. Ayuso, M. Virumbrales-Muñoz, L.J. Fernández, I. Ochoa, V.M. Perez-Garcia, M. PešicOxidative Medicine and Cellular Longevity 2019, 3061607 (2019)
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Changes in the retreatment radiation tolerance of the spinal cord with time after the initial treatmentT.E. Wooley, J. Belmonte-Beitia, G.F. Calvo, J.W. Hopewell, E.A. Gaffney and B. JonesInternational Journal of Radiation Biology 94:6, 515-531 (2018)
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Regulation of the oxidative balance with Coenzyme Q10 sensitizes human glioblastoma cells to radiation and temozolomideJ. Frontiñán, R. Santiago, C. Nieva, G. Ferrín, A. Martínez, M.V. Gomez, M. Moreno, J. Ariza, E. Lozano, J. Arjona, A. Gil, M. De la Mata, M. Pesic, J.R. Peinado, J.M. Villalba, L.A. Pérez-Romasanta, V.M. Pérez-García, F.J. Alcaín, M. Durán-PradoRadiotherapy and Oncology 128(2) 236-244 (2018)
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Non-Standard Radiotherapy Fractionations Delay the Time to Malignant Transformation in Low-Grade GliomasA. Henares-Molina, S. Benzekry, P.C. Lara, M. García-Rojo, V.M Pérez-García, A. Martínez-GonzálezPLoS One 12(6):e0178552 (2017)
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Optimized radiotherapy protocols delay the malignant transformation of low-grade gliomas in-silicoA. Henares-Molina, S. Benzecry, P. Lara, M. García-Rojo, V.M. Pérez-García, A. Martínez-GonzálezNeuro Oncol (2017) 19 (3): iii12.
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Extreme protraction for low grade gliomas: Theoretical proof of concept of a novel therapeutical strategyV.M. Pérez-García, L.A. Pérez-RomasantaMathematical Medicine and Biology 33(3) 253-271 (2016).
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Combined therapies of antithrombotics and antioxidants delay in silico brain tumors progressionA. Martínez-González, M. Durán-Pardo, G.F. Calvo, F.J. Alcaín, L.A. Pérez-Romasanta, V.M. Pérez-GarcíaMathematical Medicine and Biology 32, 239-262 (2015)
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Mathematical models for low-grade gliomas predict alternative radiotherapy fractionations with improved survivalV.M. Pérez-GarcíaITM Web of Conferences 5, 00006 (2015)
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Delay effects in the response of low grade gliomas to radiotherapy: A mathematical model and its therapeutical implicationsV.M. Pérez-García, M. Bogdanska, A. Martínez-González, J. Belmonte, P. Shucht, L.A. Pérez-RomasantaMathematical Medicine and Biology 32, 307-329 (2015)
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Mathematical model predicts response to radiotherapy of grade II gliomasL.A. Pérez-Romasanta, J. Belmonte-Beitia, A. Martínez-González, G.F. Calvo, V.M. Pérez-GarcíaReports of Practical Oncology and Radiotherapy 18, S63 (2013)
Projects
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James S. Mc. Donnell Foundation (USA) (2018 - 2021)
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Ministerio de Economía y Competitividad (2013 - 2015)
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Ministerio de Economía y Competitividad (2016 - 2019)
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Junta de Comunidades de Castilla-La Mancha (2018 - 2021)
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Ministerio de Ciencia e Innovación (Spain) (2020 - 2023)
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James S. Mc. Donnell Foundation (USA) (2012 - 2014)
Collaborators
Mathematical modeling will be developed and enriched in collaboration with Guillermo Lorenzo (University of Texas, USA), Alessandro Reali (University of Pisa) and Hector Gómez (Purdue University, USA). Clinical expertise will be provided by Luis Pérez-Romasanta, radiologist at Hospital Universitario de Salamanca.