Mathematics and brain metastasis
Brain metastases are cancer cells that spread to the brain from tumors in other organs in the body, which happens in 10% – 35% of adult cancer patients. Estimating prognosis in brain metastasis is clinically relevant, as it allows clinicians to recommend treatments that balance durability of intracranial tumor control with quality of life and side effects of treatment. We develop and use mathematical models to understand the response of these secondary tumors to radiotherapy and provide image-based biomarkers of survival and response as well as designing optimized treatments.
Publications
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Mathematical modeling of brain metastases growth and response to therapies: A reviewBeatriz Ocaña-Tienda, Víctor M. Pérez-GarcíaMathematical Biosciences 373, 109207 (2024)
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Morphological MRI features as prognostic indicators in brain metastasesOcaña-Tienda B, Pérez-Beteta J, Ortiz de Mendivil A, Asenjo B, Albillo D, Pérez-Romasanta LA, LLorente M, Carballo N, Arana E, Pérez-García VM.Cancer Imaging 24, 111 (2024)
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Radiation necrosis after radiation therapy treatment of brain metastases: A computational approachBeatriz Ocana-Tienda, Odelaisy Leon-Triana, Julian Perez-Beteta, Juan Jiménez-Sánchez, Victor M. Perez-GarciaPLOS Computational Biology 20(1) e1011400 (2024)
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Volumetric Analysis: Rethinking Brain Metastases Response AssessmentB Ocaña-Tienda, J Pérez-Beteta, JA Romero-Rosales, B Asenjo, A Ortiz, LA Pérez Romasanta, JD Albillo, F Nagib, M Vidal Denis, B. Luque, E. Arana, VM Pérez-GarcíaNeuro-Oncoloy Advances 6(1), 1-9 (2024)
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A comprehensive dataset of annotated brain metastasis MR images with clinical and radiomic dataOcaña-Tienda B, Pérez-Beteta J, Villanueva JD, Romero JA, Molina D, Suter Y, Asenjo B, Albillo D, Ortiz A, Pérez-Romasanta LA, González E, Llorente M, Carballo N, Nagib F, Vidal M, Luque B, Reyes M, Arana E, Pérez-García VMScientific Data 10, 208 (2023)
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Growth dynamics of brain metastases differentiate radiation necrosis from recurrenceB. Ocaña-Tienda, J. Pérez-Beteta, D. Molina-García, B. Asenjo, A. Ortiz de Mendivil, D. Albillo, LA Pérez-Romasanta, E. González del Portillo, M. Llorente, N. Carballo, E. Arana, Víctor M Pérez-GarcíaNeurooncology Advances 5(1), vdac179 (2023)
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Growth exponents reflect evolutionary processes and treatment response in brain metastasesB. Ocaña-Tienda, J. Pérez-Beteta, D. Molina-García, J. Jiménez-Sánchez, O. Leon-Triana, A. Ortiz de Mendivil, B. Asenjo, D. Albillo, L. Pérez-Romasanta, M. Valiente, L. Zhu, P. García- Gómez, E. González-Del Portillo, M. Llorente, N. Carballo, E. Arana, V. M. Pérez-Garcíanpj Systems Biology and Applications 9, 35 (2023)
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Brain Metastasis Response to Stereotactic Radio Surgery: A Mathematical ApproachO. León-Triana, J. Pérez-Beteta, D. Albillo, A. Ortiz de Mendivil, L.A. Pérez-Romasanta, E. González del Portillo, M. Llorente, N. Carballo, E. Arana, V.M. Pérez-GarcíaMathematics 9(7) 716 (2021)
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Universal scaling laws rule explosive growth in human cancersV.M. Pérez-García, G.F. Calvo, J.J. Bosque, O. León-Triana, J. Jiménez-Sánchez, J. Pérez-Beteta, J. Belmonte-Beitia, M. Valiente, L. Zhu, P. García-Gómez, P. Sánchez-Gómez, E. Hernández, R. Hortigüela, Y. Azimzade, D. Molina-García, A.Martínez-Rubio, A. Acosta, A. Ortiz de Mendivil, F. Vallette, P. Schucht, M. Murek, M.Pérez-Cano, D.Albillo, AF Honguero, G.A. Jiménez, E. Arana, AM García-VicenteNature Physics 16, 1232-1237 (2020)
Collaborators
Clinical aspects are addressed in collaboration with the radiologists Estanislao Arana, Beatriz Asenjo, Ana Ortiz de Mendivil and David Albillo, the radiation oncologist Luis Pérez Romasanta and the neuroscientist and leader of the Brain Metastasis Group at the CNIO, Manuel Valiente. Johanna A. Joyce (Ludwig Institute for Cancer Research and University of Lausanne, Switzerland).
