Mathematics against leukemias
Acute Lymphoblastic Leukemias are the type of cancer with the highest incidence in children. Although 80% of patients are cured with current therapeutic approaches, a fraction of patients still relapse and die because of the disease. Standard management of the disease requires a risk classification in three groups depending on several factors and a therapy that consists of three stages: induction, consolidation and maintenance, each with specific combinations of different drugs. We intend to use mathematical algorithms to improve patient classification, identify relapse risk and design personalized treatments by better using the large amount of data available.
Publications
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The shape of cancer relapse: Topological data analysis predicts recurrence in paediatric acute lymphoblastic leukaemiaS. Chulián, B. J. Stolz, A. Martínez-Rubio, C. Blázquez-Goñi, J. F. Rodríguez, T. Caballero, A. Molinos, M. Ramírez-Orellana, A. Castillo, J. L. Fuster, A. Minguela, M. V. Martínez, M. Rosa, V. M. Pérez-García, H. Byrne(submitted, 2022)
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A Mathematical Description of the Bone Marrow Dynamics of CAR T-Cell Therapy in B-cell Childhood Acute Lymphoblastic LeukemiaA. Martínez-Rubio, S. Chulián, C. Blázquez Goñi, A. Pérez Martínez, M. Ramírez Orellana, A. Navarro-Zapata, C. Ferreras, V.M. Pérez-García, M. RosaInternational J. of Molecular Sciences 22, 6371 (2021)
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CAR T cell therapy in B-cell acute lymphoblastic leukaemia: Insights from mathematical modelsO. León-Triana, S. Sabir, G.F. Calvo, J. Belmonte-Beitia, S. Chulian, A. Martínez-Rubio, M. Rosa, A. Pérez-Martínez, M. Ramírez-Orellana, V.M. Pérez-GarcíaComm Nonlin Sci Numer Simul 94, 105570 (2021)
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CAR T cells for T-cell leukemias: Insights from mathematical modelsV.M. Pérez-García, O. León-Triana, M. Rosa, A. Pérez-MartínezComm Nonlin Sci Numer Simul, 96, 105684 (2021)
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Dynamical properties of feedback signalling in B lymphopoiesis: A mathematical modelling approachS. Chulián, A. Martínez-Rubio, A. Marciniak-Czochra, T. Stiehl, C.B. Goñi, J.F. Rodríguez Gutiérrez, M.R. Orellana, A.C. Robleda, V.M. Pérez-García, M. RosaJournal of Theoretical Biology 110685 (2021)
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High-dimensional Analysis of Single-cell Flow Cytometry Data Predicts Relapse in Childhood Acute Lymphoblastic LeukemiaS. Chulián, A. Martínez-Rubio, V.M. Pérez-García, M. Rosa, C. Blázquez-Goñi, J.F. Rodríguez Gutiérrez, L. Hermosín-Ramos, A. Molinos-Quintana, T. Caballero-Velázquez, M. Ramírez-Orellana, A. Castillo Robleda, J.L Fernández-MartínezCancers 13(1), 17 (2021).
Projects
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FECYT: Fundación Española para la Ciencia y la Tecnología (2018 - 2020)
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Ministerio de Ciencia e Innovación (Spain) (2020 - 2023)
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Junta de Andalucía (2020 - 2023)