Mathematical models for the digital transition in neuro-oncology: In-silico design of a clinical trial for glioblastoma (ISGBM)
Gliomas are incurable primary brain tumors that arise from the glia, the cells that give mechanical and functional support to the neurons. Their highest grade, glioblastomas, are very aggressive and deadly. On the contrary, low grade gliomas are slowly growing, but they affect young patients and cause an important loss of years and substantial reduction in the quality of life. Both low and high grade gliomas are usually treated with surgery, chemotherapy and radiotherapy, but the optimal way of using and combining these therapies is not well known. Maximizing the effect from the available therapies is an important task with consequences to the quality of life and survival of the patients.