Immunity and immunotherapies
The immune system is the complex set of biological defenses that fight infections and other diseases such as cancer. Many aspects of the immune system are not yet completely understood and mathematical models shed light on how the different subsystems interact and develop specific immune responses. However, the immune system does not always eliminate tumor cells, as these develop mechanisms to evade it. Immunotherapies stimulate the immune system to increase the body’s antitumor response. Mathematical models help in understanding the details of the actions of immunotherapies, in developing image-based biomarkers of response, and in designing more effective therapeutic approaches.
Topics
Dynamics of the control of T cell leukemias with CAR T cell treatment.
Description of the bone marrow during CAR T cell therapy in B cell acute lymphoblastic leukemia.
Modelling of tumor-immune cell interactions.
Optimization of CAR T cell treatments of B cell lymphoma.
Publications
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Deterministic reprogramming of neutrophils within tumorsM.S.F. Ng, I. Kwok, L. Tan, C. Shi, D. Cerezo, Y. Tan, K. Leong, G.F. Calvo, K. Yang, Y. Zhang, J. Jin, K.H. Liong, D. Wu, R. He, ..., A. Hidalgo, F. Ginhoux, L.G. NgScience 383, eadf6493 (2024)
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Mathematical model of CAR-T-cell therapy for a B-cell Lymphoma lymph nodeS. Sabir, O. León-Triana, S, Serrano, R, Barrio, V. M. Pérez-Garcíaarxiv.org/abs/2409.01164
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Understanding the role of B cells in CAR T-cell therapy in leukemia through a mathematical modelS. Serrano, R. Barrio, A. Martínez-Rubio, J. Belmonte-Beitia, V. M. Pérez-GarcíaChaos 34, 083142 (2024)
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Variable selection for dimensionality reduction of biological datasets through bootstrapping of correlation networksD.G. Aragones, M. Palomino, J. Sicilia, G. Crainiciuc, I. Ballesteros, F. Sánchez-Cabo, A. Hidalgo, G.F. CalvoComputers in Biology and Medicine 168, 107827 (2024).
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On the Analysis of a Mathematical Model of CAR-T Cell Therapy for Glioblastoma: Insights from a Mathematical ModelBodnar, M ; Forys, U ; Piotrowska, MJ ; Bodzioch, M ; Romero-Rosales, JA; Belmonte-Beitia, JInternational Journal of Applied Mathematics and Computer Science 33(3), 379-394 (2023)
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The local microenvironment drives activation of neutrophils in human brain tumorsMaas RR, Soukup K, Fournier N, Massara M, Galland S, Kornete M, Wischnewski V, Lourenco J, Croci D, Álvarez-Prado ÁF, Marie DN, Lilja J, Marcone R, Calvo GF, Santalla Mendez R, Aubel P, Bejarano L, Wirapati P, Ballesteros I, Hidalgo A, Hottinger AF, Brouland JP, Daniel RT, Hegi ME, Joyce JACell 186, 1-21 (2023)
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Behavioural immune landscapes of inflammationCrainiciuc G, Palomino-Segura M, Molina-Moreno M, Sicilia J, Aragones DG, Li JLY, Madurga R, Adrover JM, Aroca-Crevillén A, Martin-Salamanca S, Del Valle AS, Castillo SD, Welch HCE, Soehnlein O, Graupera M, Sánchez-Cabo F, Zarbock A, Smithgall TE, Di Pilato M, Mempel TR, Tharaux PL, González SF, Ayuso-Sacido A, Ng LG, Calvo GF, González-Díaz I, Díaz-de-María F, Hidalgo A.Nature 601, 415-421 (2022)
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Dynamics and analysis of a mathematical model of neuroblastoma treated with CelyvirJ. García Otero, A. Alvarez Arenas, J. Belmonte BeitiaApplied Mathematical Modelling 110 (2022) 131-148
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A Mathematical Description of the Bone Marrow Dynamics of CAR T-Cell Therapy in B-cell Childhood Acute Lymphoblastic LeukemiaA. Martínez-Rubio, S. Chulián, C. Blázquez Goñi, A. Pérez Martínez, M. Ramírez Orellana, A. Navarro-Zapata, C. Ferreras, V.M. Pérez-García, M. RosaInternational J. of Molecular Sciences 22, 6371 (2021)
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CAR T cell therapy in B-cell acute lymphoblastic leukaemia: Insights from mathematical modelsO. León-Triana, S. Sabir, G.F. Calvo, J. Belmonte-Beitia, S. Chulian, A. Martínez-Rubio, M. Rosa, A. Pérez-Martínez, M. Ramírez-Orellana, V.M. Pérez-GarcíaComm Nonlin Sci Numer Simul 94, 105570 (2021)
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CAR T cells for T-cell leukemias: Insights from mathematical modelsV.M. Pérez-García, O. León-Triana, M. Rosa, A. Pérez-MartínezComm Nonlin Sci Numer Simul, 96, 105684 (2021)
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Dual-Target Car-Ts With on- and off-Tumour Activity May Override Immune Suppression in Solid Cancers: A Mathematical Proof of ConceptO. León-Triana, A. Pérez-Martínez, M. Ramírez-Orellana, V.M. Pérez-GarcíaCancers 13, 703 (2021)
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Co-option of Neutrophil Fates by Tissue EnvironmentsI. Ballesteros, A. Rubio, M. Genua, E. Lusito, I. Kwok, G.F. Calvo, T.E. Khoyratty, E. van Grinsven, S. González, J.A. Nicolás, T. Vicanolo, A. Maccataio, A. Benguría, J.L. Li, J.M. Adrover, A. Aroca, J.A. Quintana, S. Martín, F. Mayo, S. Ascher, G. Barbiera, O. Soehnlein, M. Gunzer, F. Ginhoux, F. Sánchez, E. Nistal, C. Schulz, A. Dopazo, C. Reinhardt, I.A. Udalova, L.G. Ng, R. Ostuni, A. HidalgoCell 183(5), 1282-1297 (2020)
Projects
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Ministerio de Economía y Competitividad (2016 - 2019)
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Ministerio de Ciencia e Innovación (Spain) (2020 - 2023)
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NeN Association (2020 - 2023)
Collaborators
Extensive research experience and knowledge on immunology are provided by Andrés Hidalgo, senior researcher at CNIC and professor of the Immunobiology Department at Yale University, and Iván Ballesteros, biologist and associate researcher at CNIC. Clinical aspects will be addressed in collaboration with the Spanish Group of Hematopoietic Transplants (GETH); Manuel Ramírez Orellana, pediatric oncologist and director of the Unit for Cell and Gene Therapies at Hospital Infantil Universitario Niño Jesús; and Dr Antonio Pérez Martínez, pediatric oncologist at Hospital La Paz and head of the Translational Research group on Childhood Cancer at IdiPAZ. Maria Alieva (Instituto de Investigaciones Biomédicas “Alberto Sols”, CSIC, Madrid, Spain). Johanna A. Joyce (Ludwig Institute for Cancer Research and University of Lausanne, Switzerland). Andrés Hidalgo e Iván Ballesteros ya aparecen recogidos.
