Imaging Biomarkers in Glioblastoma
Glioblastoma is the most frequent and aggressive malignant primary brain tumor, with patient median survival of only 14 months from diagnosis. High resolution magnetic resonance imaging is routine for diagnosis, treatment planning, response evaluation and follow-up. We reconstruct the tumors in 3D and use mathematics to identify ‘hidden’ features (e.g. morphological or textural properties) related to patient prognosis and allowing to personalize treatments.
Publications
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Multiple and diffuse gliomas by 18F-Fluorocholine PET/CT: two sides of the same coinA. M. García Vicente, J. Pérez-Beteta, J. J. Bosque, A. M. Soriano, V. M. Pérez-GarcíaClinical Nuclear Medicine 47(6), e457-e465 (2022)
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A mesoscopic simulator to uncover heterogeneity and evolutionary dynamics in tumorsJ. Jiménez-Sánchez, A. Martínez-Rubio, A. Popov, J. Pérez-Beteta, Y. Azimzade, D. Molina-García, J. Belmonte-Beitia, G.F. Calvo, V.M. Pérez-GarcíaPLoS Computational Biology 17(2) e1008266 (2021).
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Tumor width on T1-weighted MRI images of glioblastoma as a prognostic biomarker: A mathematical modelJ. Pérez Beteta, J. Belmonte-Beitia, V.M. Pérez-GarcíaMathematical Modelling of Natural Phenomena 15, 10 (2020)
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Universal scaling laws rule explosive growth in human cancersV.M. Pérez-García, G.F. Calvo, J.J. Bosque, O. León-Triana, J. Jiménez-Sánchez, J. Pérez-Beteta, J. Belmonte-Beitia, M. Valiente, L. Zhu, P. García-Gómez, P. Sánchez-Gómez, E. Hernández, R. Hortigüela, Y. Azimzade, D. Molina-García, A.Martínez-Rubio, A. Acosta, A. Ortiz de Mendivil, F. Vallette, P. Schucht, M. Murek, M.Pérez-Cano, D.Albillo, AF Honguero, G.A. Jiménez, E. Arana, AM García-VicenteNature Physics 16, 1232-1237 (2020)
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18F-Fluorocholine PET/CT in the prediction of molecular subtypes and prognosis for gliomas.A.M. Garcia Vicente, J. Perez-Beteta, M. Amo-Salas, F.J. Pena Pardo, M. Villena, H. Sandoval, M. Mollejo, R. Barbella, C.J. Klein, J.M. Borras, A.M. Soriano, V.M. Pérez-GarcíaClinical Nuclear Medicine 44(10) e548-e558 (2019).
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Morphologic features on MR imaging classify multifocal glioblastomas in different prognostic groupsJ. Pérez-Beteta, D. Molina, M. Villena, M. Rodríguez, C. Velásquez, J. Martino, B. Meléndez, A.R. de Lope, R. Morcillo, J. Sepúlveda, A. Hernández, A. Ramos, J. Barcia, P. Lara, D. Albillo, A. Revert, E. Arana, V.M. Pérez-GarciaAmerican Journal of Neuro-radiology 40 (4) 634-640 (2019).
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Morphological MRI-based features provide pretreatment and post-surgery survival prediction in glioblastomaJ. Pérez-Beteta, D. Molina-García, A. Martínez-González, M. Amo, A. Henares-Molina, B. Luque, E. Arregui, M. Calvo, J.M.Borrás, J. Martino, C. Velasquez, B. Meléndez, A.R. de Lope, R. Moreno, J.A. Barcia, B. Asenjo, M. Benavides, I. Herruzo, P.C. Lara, R. Cabrera, D. Albillo, M. Navarro, L.A. Pérez-Romasanta, A. Revert, E. Arana, V.M. Pérez-GarcíaEuropean Radiology 29(4) 1968-1977 (2019)
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Prognostic models based on imaging findings in glioblastoma: Human versus MachineD. Molina-García, L. Vera, J. Pérez-Beteta, E. Arana, V.M. Pérez-GarcíaScientific Reports 9:5982 (2019)
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A three-dimensional computational analysis of magnetic resonance images characterizes the biological aggressiveness in malignant brain tumorsJ. Pérez-Beteta, A. Martínez-González, V.M. Pérez-GarcíaJournal of the Royal Society Interface 15, 20180503 (2018).
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Tumor Surface Regularity at MR Imaging Predicts Survival and Response to Surgery in Patients with GlioblastomaJ. Pérez-Beteta, D. Molina, A. Fernández, B. Luque, E. Arregui, M. Calvo, J. M. Borrás, A. Fernández-Romero, B. Luque, B. Meléndez, A.R. de Lope, R. Moreno, L. Iglesias, J.A. Barcia, J. Martino, C. Velasquez, B. Asenjo, M. Benavides, I. Herruzo, A. Revert, E. Arana, V. M. Pérez-GarcíaRadiology 288(1), 218-225 (2018)
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Glioblastoma: Does the pre-treatment geometry matter? A postcontrast T1 MRI-based studyJ. Pérez-Beteta, A. Martínez-González, D. Molina, M. Amo, B. Luque, E. Arregui, M. Calvo, J. M. Borrás, C. López, M. Claramonte, J. Barcia, L. Iglesias, J. Avecillas, D.Albillo, M. Navarro, J.M. Villanueva, J.C. Paniagua, J. Martino, C. Velasquez, B. Asenjo, M. Benavides, I. Herruzo, M.C. Delgado, A. Del Valle, A. Falkov, P. Schucht, E. Arana, L. Pérez-Romasanta, V. M.Pérez-GarcíaEuropean Radiology 27(3), 1096-1104 (2017)
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Novel geometrical imaging biomarkers predict survival and allow for patient selection for surgery in glioblastoma patientsJ. Pérez-Beteta, D. Molina, A. Martínez-González, E. Arregui, B. Asenjo, L. Iglesias, J. Martino, L. Pérez-Romasanta, E. Arana, V.M. Pérez-GarcíaNeuro-Oncology 19(3):iii80-iii80 (2017)
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Towards individualized survival prediction in glioblastoma patients using machine learning methodsL. Vera, J. Pérez-Beteta, D. Molina, J.M. Borrás, M. Benavides, J.A. Barcia, C. Velásquez, D. Albillo, P. Lara, V.M. Pérez-GarcíaNeuro-Oncology 19(3):iii84-iii84 (2017)
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Geometrical measures obtained from pretreatment postcontrast T1 weighted MRIs predict survival benefits from bevacizumab in glioblastoma patientsD. Molina, J. Pérez-Beteta, A. Martínez-González, J.M. Sepúlveda, S. Peralta, M. Gil-Gil, G. Reynes, A. Herrero, R. De Las Peñas, R. Luque, J. Capellades, C. Balaña, V.M. Pérez-GarciaPLoS One 11(8) e0161484 (2016).
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Tumour heterogeneity in glioblastoma assessed by MRI texture analysis: a potential marker of survival.D. Molina, J. Pérez-Beteta, B. Luque, E. Arregui, M. Calvo, J. M. Borrás, C. López, J. Martino, C. Velasquez, B. Asenjo, M. Benavides, I. Herruzo, A. Martínez-González, E. Arana. L. Pérez, V. M. Pérez-GarcíaBritish Journal on Radiology 89, 2016242 (2016)
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Bright solitary waves in malignant gliomas.V.M. Pérez-García, G.F. Calvo, J. Belmonte-Beitia, D. Diego, L.A. Pérez-RomasantaPhysical Review E 84, 021921 (2011)
Projects
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James S. Mc Donnell Foundation (USA) (2015 - 2016)
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James S. Mc. Donnell Foundation (USA) (2018 - 2021)
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Ministerio de Economía y Competitividad (2016 - 2019)
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Junta de Comunidades de Castilla-La Mancha (2018 - 2021)
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Ministerio de Ciencia e Innovación (Spain) (2020 - 2023)
Collaborators
Imaging biomarkers in glioblastoma is a multidisciplinary research line with an extensive database of high-quality medical images, clinical information, and the participation of clinical personnel from different services of the following institutions: Hospital 12 de Octubre de Madrid (Spain), Hospital General de Ciudad Real (Spain), Hospital Universitario Marqués de Valdecilla de Santander (Spain), Hospital Universitario de Toledo (Spain), Hospital Regional Universitario de Málaga (Spain), Hospital Universitario de Salamanca (Spain), Hospital de Manises (Spain) and Toronto Western Hospital (Canada).
- Luis Vera Ramírez
- Carlos Velásquez Rodríguez
- Juan M. Sepúlveda
- Philippe Schucht
- Pilar Sánchez-Gómez
- Ana Ramos González
- Luis Pérez Romasanta
- Victor M. Pérez García
- Julián Pérez Beteta
- David Molina García
- Bárbara Meléndez-Asensio
- Álvaro Martínez Rubio
- Alicia Martínez González
- Belén Luque Sánchez
- Juan Jiménez Sánchez
- Ismael Herruzo Cabrera
- Aurelio Hernández-Laín
- Araceli Henares Molina
- Ana M. García Vicente
- Manuel Benavides
- Beatriz Asenjo Martínez
- Estanislao Arana Fernández de Moya
- José David Albillo Labarra
