Biomarkers in lung cancer

Lung and bronchus cancer is responsible for the most deaths by a substantial margin. While late stage cancers are difficult to treat, early stage cancers may still have windows of opportunity to treat them with potentially curative intent. It is very interesting to have ways of assessing non-invasively the aggressiveness of lessions identified on TC and to adjust treatments accordingly.

Publications

Metabolic Activity Grows in Human Cancers Pushed by Phenotypic Variability

J.J. Bosque, G.F. Calvo, D. Molina-García, J. Pérez-Beteta, A.M. García Vicente, V. M. Pérez-García

iScience 26(3) 106118 (2023)
SUVmax to tumor perimeter distance: a robust radiomics prognostic biomarker in resectable non-small cell lung cancer patients

G. A. Jiménez-Londoño, A. M. García Vicente, J. J. Bosque, M. Amo-Salas, J. Pérez-Beteta, A. F. Honguero-Martinez, V. M. Pérez-García, A. M. Soriano

European Radiology 32, 3889-3902 (2022)
Evolutionary dynamics at the tumor edge reveals metabolic imaging biomarkers

J. Jiménez-Sánchez, J.J. Bosque, G.A. Jiménez-Londoño, D. Molina-García, A. Martínez-Rubio, J. Pérez-Beteta, C. Ortega-Sabater, A.F Honguero-Martínez, A.M. García-Vicente, G.F. Calvo, V.M. Pérez-García

Proceedings of the National Academy of Sciences (USA) 118(6) e2018110118 (2021).
Universal scaling laws rule explosive growth in human cancers

V.M. Pérez-García, G.F. Calvo, J.J. Bosque, O. León-Triana, J. Jiménez-Sánchez, J. Pérez-Beteta, J. Belmonte-Beitia, M. Valiente, L. Zhu, P. García-Gómez, P. Sánchez-Gómez, E. Hernández, R. Hortigüela, Y. Azimzade, D. Molina-García, A.Martínez-Rubio, A. Acosta, A. Ortiz de Mendivil, F. Vallette, P. Schucht, M. Murek, M.Pérez-Cano, D.Albillo, AF Honguero, G.A. Jiménez, E. Arana, AM García-Vicente

Nature Physics 16, 1232-1237 (2020)
Interplay of Darwinian Selection, Lamarckian Induction and Microvesicle Transfer on Drug Resistance in Cancer.

A. Alvarez-Arenas, A. Podolski-Renic, J. Belmonte-Beitia, M. Pesic, G.F. Calvo

Scientific Reports 9:9332 (2019)

Collaborators

We work on extracting biomarkers from lung cancer PET images in collaboration with the Hospitals of Albacete (Antonio Honguero), Ciudad Real (Germán Jiménez) and Toledo (Ana García). We also collaborate with large cancer screening programs through the Instituto Valenciano de Oncología (Estanislao Arana).

Biomarkers in lung cancer

Publications

Collaborators

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