Big data and biomarker design

An ever-increasing amount of available data in cancer research, obtained from various ‘omics’ technologies (genomics, radiomics, proteomics, etc.), remains underutilized. This data holds potential for diagnosing cancer types, planning therapy, assessing response, and monitoring progress. We study the properties of existing tumor quantifiers (e.g., heterogeneity, morphological features) to identify those that can serve as indicators of disease status. Additionally, we introduce new properties derived from mathematical models, which could function as prognostic and response biomarkers. Furthermore, we investigate methods to combine these biomarkers into more sophisticated prognostic and predictive models.


There are no publications on this topic yet, but they are coming



Big data and biomarker design at MOLAB is developed in collaboration with Estanislao Arana (Fundación Instituto Valenciano de Oncología, Valencia, Spain) and Mauricio Reyes and is Medical Image Analysis group (ARTORG center, Bern, Switzerland). To this end, medical imaging and clinical data have been provided by our collaborators in different medical institutions: Hospital 12 de Octubre de Madrid, Hospital General de Ciudad Real, Hospital Universitario Marqués de Valdecilla de Santander, Hospital Virgen de la Salud de Toledo, Hospital Regional Universitario de Málaga, MD Anderson Cancer Center de Madrid, Hospital Universitario de Sanchinarro de Madrid, Hospital Universitario de Salamanca, Hospital de Manises and Instituto Valenciano de Oncología.

Andrés Hidalgo(Yale Shool of Medicine, New Haven, Connecticut, USA); Iván Ballesteros (CNIC-Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain); Manuel Ramírez Orellana (Hospital Infantil Universitario Niño Jesús, Madrid, Spain); Francisco Monroy Muñoz (Hospital Universitario 12 de Octubre, Madrid, Spain); Carlos Torroja Fungairiño (CNIC-Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain); Diego Herráez Aguilar (Universidad Francisco de Vitoria, Madrid, Spain).