Cell therapies have become a novel tool in oncology for the treatment of aggressive and/or metastatic advanced tumors. In this project we will study two of them focusing on neuroblastoma. First, we will study mathematically the clinical trial of Celyvir, whose basis is mesenchymal stem cells loaded with an oncolytic virus, with the goal of improving its effectiveness. Secondly we will consider mathematically novel strategies to improve CAR-T effectiveness in neuroblastoma.