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“Graduate (1991) PhD (Complutense U., Madrid, 1995). Associate professor (1997) and full professor (2002) in Applied Mathematics at the Mathematics Department of the University of Castilla-La Mancha. He has published more than 170 research papers with more than 11000 Google citations and has an H-index of 52. He is editor in chief of the journal “Physica D: “Nonlinear Phenomena” and serves in the editorial board of “npj Systems Biology and Applications”. He is the coordinator of the Applied Mathematics panel at the Spanish National Research Agency and has been a member of the Marie Curie evaluation committee and of many international project evaluation boards in oncology and/or applied mathematics in France, UK, Poland, Austria, Romania, Cyprus, Latvia, Spain, etc. His main field of research is the application of mathematical modeling to oncology and more specifically to brain tumors, metastasis, cellular immunotherapies, biomarkers, medical images, lymphomas, leukaemias, prostate cancer, etc. In this field he has led several projects funded by public institutions, private foundations such as the James S. Mc. Donnell Foundation and pharmaceutical companies such as NOVARTIS. More specifically he is interested in the development and validation of mechanistic mathematical models that shed light on oncological processes and may be used as platforms to personalize treatments and develop in-silico trials. Also he is interested in the development of mathematical model-based biomarkers of response to treatments.” |
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A comprehensive dataset of annotated brain metastasis MR images with clinical and radiomic data
Scientific Data 10, 208 (2023)
Ocaña-Tienda B, Pérez-Beteta J, Villanueva JD, Romero JA, Molina D, Suter Y, Asenjo B, Albillo D, Ortiz A, Pérez-Romasanta LA, González E, Llorente M, Carballo N, Nagib F, Vidal M, Luque B, Reyes M, Arana E, Pérez-García VM -
Breaking Down Cell-Free DNA Fragmentation: A Markov Model Approach
biorxiv (doi:10.1101/2023.07.06.547953)
Terence H.L. Tsui, Phil F. Xie, Salvador Chulián, Víctor M. Pérez-García -
Growth exponents reflect evolutionary processes and treatment response in brain metastases
npj Systems Biology and Applications 9, 35 (2023)
B. Ocaña-Tienda, J. Pérez-Beteta, D. Molina-García, J. Jiménez-Sánchez, O. Leon-Triana, A. Ortiz de Mendivil, B. Asenjo, D. Albillo, L. Pérez-Romasanta, M. Valiente, L. Zhu, P. García- Gómez, E. González-Del Portillo, M. Llorente, N. Carballo, E. Arana, V. M. Pérez-García -
Metabolic Activity Grows in Human Cancers Pushed by Phenotypic Variability
iScience 26(3) 106118 (2023)
J.J. Bosque, G.F. Calvo, D. Molina-García, J. Pérez-Beteta, A.M. García Vicente, V. M. Pérez-García -
Radiation necrosis after radiation therapy treatment of brain metastases: A computational approach
biorxiv (2023)
Beatriz Ocana-Tienda, Odelaisy Leon-Triana, Julian Perez-Beteta, Victor M. Perez-Garcia -
Stochastic Fluctuations Drive Non-genetic Evolution of Proliferation in Clonal Cancer Cell Populations
Bulletin of Mathematical Biology 85(1) 8 (2023)
C Ortega-Sabater, GF Calvo, Jelena Dinic, Ana Podolski, Milica Pesic, VM Perez-Garcia -
The shape of cancer relapse: Topological data analysis predicts recurrence in paediatric acute lymphoblastic leukaemia
PLOS Computational Biology 19(8) e1011329 (2023)
S. Chulián, B. J. Stolz, A. Martínez-Rubio, C. Blázquez-Goñi, J. F. Rodríguez, T. Caballero, A. Molinos, M. Ramírez-Orellana, A. Castillo, J. L. Fuster, A. Minguela, M. V. Martínez, M. Rosa, V. M. Pérez-García, H. Byrne -
Growth dynamics of brain metastases differentiate radiation necrosis from recurrence
Neurooncology Advances (2022) vdac179
B. Ocaña-Tienda, J. Pérez-Beteta, D. Molina-García, B. Asenjo, A. Ortiz de Mendivil, D. Albillo, LA Pérez-Romasanta, E. González del Portillo, M. Llorente, N. Carballo, E. Arana, Víctor M Pérez-García -
Mathematical models of leukaemia and its treatment: a review
SEMA Journal 79, 441-486 (2022)
S. Chulián, Á. Martínez-Rubio, M. Rosa, V. M. Pérez-García -
Multiple and diffuse gliomas by 18F-Fluorocholine PET/CT: two sides of the same coin
Clinical Nuclear Medicine 47(6), e457-e465 (2022)
A. M. García Vicente, J. Pérez-Beteta, J. J. Bosque, A. M. Soriano, V. M. Pérez-García -
On optimal temozolomide scheduling for slowly growing glioblastomas
Neuro-Oncology Advances 4(1), vdac155, 1-13 (2022)
B. Segura-Collar, J. Jiménez-Sánchez, R. Gargini, M. Dragoj, J. M. Sepúlveda, M. Pesic, M. A. Ramírez, L. E. Ayala-Hernández, P.Sánchez-Gómez, V. M Pérez-García -
Patient-specific forecasting of post-radiotherapy prostate-specific antigen kinetics enables early prediction of biochemical relapse
iScience 25, 105430 (2022)
G. Lorenzo, N. di Muzio, C. L. Deantoni, C. Cozzarini, A. Fodor, A. Briganti, F. Montorsi, V. M. Pérez-García, H. Gómez, A. Reali -
SUVmax to tumor perimeter distance: a robust radiomics prognostic biomarker in resectable non-small cell lung cancer patients
European Radiology 32, 3889-3902 (2022)
G. A. Jiménez-Londoño, A. M. García Vicente, J. J. Bosque, M. Amo-Salas, J. Pérez-Beteta, A. F. Honguero-Martinez, V. M. Pérez-García, A. M. Soriano
- Administration of coenzyme-Q plus antithrombotics could sensitize glioblastoma cells to the effect of chemotherapeuticals
James S. Mc. Donnell Foundation (USA) (2012 - 2014) - Estudio de la aleatoriedad e independencia de los resultados de apuestas automáticas generadas por el terminal de juegos
Sistemas Técnicos de Loterías del Estado (2011 - 2012) - Optimization of Glioma Treatment by Combination of Radiotherapy, Chemotherapy, Antiangiogenic and Metabolically-Targeted Therapies
James S. Mc. Donnell Foundation (USA) (2011 - 2012) - Mathematical models and multiscale methods for processes in tumor signaling and anti-tumor therapies
Ministerio de Ciencia e Innovación (2009 - 2012)

“Graduate (1991) PhD (Complutense U., Madrid, 1995). Associate professor (1997) and full professor (2002) in Applied Mathematics at the Mathematics Department of the University of Castilla-La Mancha. He has published more than 170 research papers with more than 11000 Google citations and has an H-index of 52. He is editor in chief of the journal “Physica D: “Nonlinear Phenomena” and serves in the editorial board of “npj Systems Biology and Applications”. He is the coordinator of the Applied Mathematics panel at the Spanish National Research Agency and has been a member of the Marie Curie evaluation committee and of many international project evaluation boards in oncology and/or applied mathematics in France, UK, Poland, Austria, Romania, Cyprus, Latvia, Spain, etc. His main field of research is the application of mathematical modeling to oncology and more specifically to brain tumors, metastasis, cellular immunotherapies, biomarkers, medical images, lymphomas, leukaemias, prostate cancer, etc. In this field he has led several projects funded by public institutions, private foundations such as the James S. Mc. Donnell Foundation and pharmaceutical companies such as NOVARTIS. More specifically he is interested in the development and validation of mechanistic mathematical models that shed light on oncological processes and may be used as platforms to personalize treatments and develop in-silico trials. Also he is interested in the development of mathematical model-based biomarkers of response to treatments.” |
- A comprehensive dataset of annotated brain metastasis MR images with clinical and radiomic data
Scientific Data 10, 208 (2023)
Ocaña-Tienda B, Pérez-Beteta J, Villanueva JD, Romero JA, Molina D, Suter Y, Asenjo B, Albillo D, Ortiz A, Pérez-Romasanta LA, González E, Llorente M, Carballo N, Nagib F, Vidal M, Luque B, Reyes M, Arana E, Pérez-García VM - Breaking Down Cell-Free DNA Fragmentation: A Markov Model Approach
biorxiv (doi:10.1101/2023.07.06.547953)
Terence H.L. Tsui, Phil F. Xie, Salvador Chulián, Víctor M. Pérez-García - Growth exponents reflect evolutionary processes and treatment response in brain metastases
npj Systems Biology and Applications 9, 35 (2023)
B. Ocaña-Tienda, J. Pérez-Beteta, D. Molina-García, J. Jiménez-Sánchez, O. Leon-Triana, A. Ortiz de Mendivil, B. Asenjo, D. Albillo, L. Pérez-Romasanta, M. Valiente, L. Zhu, P. García- Gómez, E. González-Del Portillo, M. Llorente, N. Carballo, E. Arana, V. M. Pérez-García - Metabolic Activity Grows in Human Cancers Pushed by Phenotypic Variability
iScience 26(3) 106118 (2023)
J.J. Bosque, G.F. Calvo, D. Molina-García, J. Pérez-Beteta, A.M. García Vicente, V. M. Pérez-García - Radiation necrosis after radiation therapy treatment of brain metastases: A computational approach
biorxiv (2023)
Beatriz Ocana-Tienda, Odelaisy Leon-Triana, Julian Perez-Beteta, Victor M. Perez-Garcia - Stochastic Fluctuations Drive Non-genetic Evolution of Proliferation in Clonal Cancer Cell Populations
Bulletin of Mathematical Biology 85(1) 8 (2023)
C Ortega-Sabater, GF Calvo, Jelena Dinic, Ana Podolski, Milica Pesic, VM Perez-Garcia - The shape of cancer relapse: Topological data analysis predicts recurrence in paediatric acute lymphoblastic leukaemia
PLOS Computational Biology 19(8) e1011329 (2023)
S. Chulián, B. J. Stolz, A. Martínez-Rubio, C. Blázquez-Goñi, J. F. Rodríguez, T. Caballero, A. Molinos, M. Ramírez-Orellana, A. Castillo, J. L. Fuster, A. Minguela, M. V. Martínez, M. Rosa, V. M. Pérez-García, H. Byrne - Growth dynamics of brain metastases differentiate radiation necrosis from recurrence
Neurooncology Advances (2022) vdac179
B. Ocaña-Tienda, J. Pérez-Beteta, D. Molina-García, B. Asenjo, A. Ortiz de Mendivil, D. Albillo, LA Pérez-Romasanta, E. González del Portillo, M. Llorente, N. Carballo, E. Arana, Víctor M Pérez-García - Mathematical models of leukaemia and its treatment: a review
SEMA Journal 79, 441-486 (2022)
S. Chulián, Á. Martínez-Rubio, M. Rosa, V. M. Pérez-García - Multiple and diffuse gliomas by 18F-Fluorocholine PET/CT: two sides of the same coin
Clinical Nuclear Medicine 47(6), e457-e465 (2022)
A. M. García Vicente, J. Pérez-Beteta, J. J. Bosque, A. M. Soriano, V. M. Pérez-García - On optimal temozolomide scheduling for slowly growing glioblastomas
Neuro-Oncology Advances 4(1), vdac155, 1-13 (2022)
B. Segura-Collar, J. Jiménez-Sánchez, R. Gargini, M. Dragoj, J. M. Sepúlveda, M. Pesic, M. A. Ramírez, L. E. Ayala-Hernández, P.Sánchez-Gómez, V. M Pérez-García - Patient-specific forecasting of post-radiotherapy prostate-specific antigen kinetics enables early prediction of biochemical relapse
iScience 25, 105430 (2022)
G. Lorenzo, N. di Muzio, C. L. Deantoni, C. Cozzarini, A. Fodor, A. Briganti, F. Montorsi, V. M. Pérez-García, H. Gómez, A. Reali - SUVmax to tumor perimeter distance: a robust radiomics prognostic biomarker in resectable non-small cell lung cancer patients
European Radiology 32, 3889-3902 (2022)
G. A. Jiménez-Londoño, A. M. García Vicente, J. J. Bosque, M. Amo-Salas, J. Pérez-Beteta, A. F. Honguero-Martinez, V. M. Pérez-García, A. M. Soriano
- Administration of coenzyme-Q plus antithrombotics could sensitize glioblastoma cells to the effect of chemotherapeuticals
James S. Mc. Donnell Foundation (USA) (2012 - 2014) - Estudio de la aleatoriedad e independencia de los resultados de apuestas automáticas generadas por el terminal de juegos
Sistemas Técnicos de Loterías del Estado (2011 - 2012) - Optimization of Glioma Treatment by Combination of Radiotherapy, Chemotherapy, Antiangiogenic and Metabolically-Targeted Therapies
James S. Mc. Donnell Foundation (USA) (2011 - 2012) - Mathematical models and multiscale methods for processes in tumor signaling and anti-tumor therapies
Ministerio de Ciencia e Innovación (2009 - 2012)