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Project on integrative CellOmics for precision medicine in childhood leukemia
MOLAB
Monday November 21, 2022

MOLAB participates as a PI in a coordinated project entitled "Integrative CellOmics for precision medicine in childhood leukemia: A coordinated eHealth action for cancer biodigitization (LEUKODOMICS)" which has been approved by the Ministerio de Ciencia e Innovación (Spain), co-funded with the NextGeneration EU funds. This project aims to create a coordinated action for the biodigitization of pediatric acute lymphoblastic leukemia (ALL), the most frequent cancer during childhood. LEUKODOMICS encompasses the development of new CellOmics technologies for functional single-cell phenotyping to be digitally pipelined alongside conventional bulk and single-cell analytics of functional genomics. It also integrates cellular regulatory landscapes into multi-omic ALL-profiles and mechanisms that determine the aggressive infiltrating nature of malignant leukocytes in pediatric ALL. It will then release precision ALL-medicine prototypes from digitized associations between functional cell phenotypes, genetic profiles, and clinical indicators of therapeutic value for pediatric patients. Within a systems biology framework, the digital data will be computationally tested and analyzed via in silico trials using digital twining (DT) with proof-of-concept cases for preclinical translation. Implementation of a LEUKODOMICS clinical decision support systems platform based on ALL-DTs will be initiated and exploited. The project involves the Niño Jesús Hospital (Coordinator and PI Dr. Manuel Ramírez Orellana), the Research Institute Hospital 12 de Octubre (PI Francisco Monroy Muñoz), the Centro Nacional de Investigaciones Cardiovasculares Carlos III (PI Carlos Torroja), the University Francisco de Vitoria (PI Diego Herráez Aguilar) and MOLAB (PI Prof. Gabriel F. Calvo).

 

 

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